Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1990-02-26
2000-07-18
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424812, 42419611, 4242041, 4242061, 4242341, 264 41, A61K 9127, A61K 39385, A61K 3912, B01J 1302
Patent
active
060904062
ABSTRACT:
A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein said liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen wherein said organic acid derivative of a sterol and immunogen are present in an immunization dose, and method according to use is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristoylphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein said DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.
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Alving Carl R.
Estis Leonard
Janoff Andrew S.
Keyes Lynn D.
Popescu Mircea C.
Dees Jos,e G.
Goodman Rosanne
Hartley Michael G.
Rubin Kenneth B.
The Liposome Company Inc.
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