Potentiation of erythropoiesis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

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435 2, 435810, 424 93, 604 4, A01N 102, C12Q 102

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050325078

ABSTRACT:
A method for modulating the rate of erythropoiesis in human hematopoietic progenitor cells. FRP is found to be an efficacious potentiator of, and inhibin a suppressor of, erythropoietin-induced differentiation. FRP and inhibin are shown to be functional antagonists of each other, and thus represent an effective means for modulating erythropoiesis in a number of disease states which are directly caused by or associated with an abnormal rate of erythropoiesis.

REFERENCES:
Sugino, H. et al., Biochem. Biophys. Res. Comm., vol. 153, No. 1, 1988, pp. 281-288.
Hasegawa, Y., et al., Biochim. Biophys. Res. Comm., vol. 156, No. 2, 1988, pp. 668-674.
Kitaoka, N., et al., Biochem. Biophys. Res., Comm., vol. 146, No. 3, 1987, pp. 1382-1385.
Yu, J., et al., Nature, vol. 330, 24/31 Dec. 1987, pp. 765-767.
Murata, M. et al., Proc. Natl. Acad. Sci. USA, vol. 85, pp. 2434-2438, Apr. 1988.
Broxmeyer, H., et al., Proc. Natl. Acad. Sci. USA, vol. 85, pp. 9052-9056, Dec. 1988.
Yu, J., et al., Blood, vol. 73, No. 4, Mar. 1989, pp. 952-960.
Eto, Y., vol. 142, No. 3, Boichem. Biophys. Res. Comm., pp. 1095-1103, Feb. 1987.
Alberts, B., et al., Molecular Biology of the Cell, Garland Publishing, New York, NY, 1983, pp. 925-926.
Schwall, R., et al., Endocrinology, vol. 125, No. 3, 1420-1423 (1989).

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