Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-04-29
1997-07-29
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514403, 514551, 514564, 514565, A61K 31415, A61K 3122, A61K 31195
Patent
active
056522550
ABSTRACT:
A human or animal subject having a solid tumour is treated by administering to the subject therapeutically effective amounts of a nitric oxide (NO) synthase inhibitor and a compound which is an imidazole or 1,2,4-triazole derivative of formula (A) ##STR1## wherein X is selected from the group consisting of ##STR2## wherein R is hydrogen or a C.sub.1 -C.sub.6 alkyl group; each of R'.sub.1 to R'.sub.5 is independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl, hydroxy(C.sub.1 -C.sub.6 alkyl), phenyl, (C.sub.1 -C.sub.6 alkyl)phenyl and phenyl(C.sub.1 -C.sub.6 alkyl); m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclisation reaction and which is not negatively-charged; or a physiologically acceptable acid addition salt thereof.
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Adams Gerald Edward
Stratford Ian James
Wood Pauline Joy
British Technology Group Limited
Goldberg Jerome D.
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