Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-27
1996-08-27
Seidleck, James J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514398, 514399, 514552, 514569, 514570, 514577, 514588, 514709, 514727, 514738, 514732, 514739, 514758, 514765, 514766, 514786, A61K 4700, A61K 3123
Patent
active
055501451
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a novel antimicrobial composition and to a process for the preparation thereof. The invention further relates to the composition for use as a pharmaceutical composition, to the use of the composition for the preparation of a pharmaceutical preparation as well as to usages of said composition as a preservative additive in cosmetic, medical or food products. More specifically, the composition contains certain special monoglycerides which potentiate the antimicrobial properties of previously known antimicrobial compounds or impart antimicrobial properties to compounds which have not in themselves been regarded as antimicrobials.
BACKGROUND TO THE INVENTION
The use of antibacterial substances is common within, by way of example, the field of dermatology. The aim of this use is partly to treat the patient with a specific antibacterial substance against some infection, e.g. antimycotics against fungal infections, partly to preserve the products against microbial contamination.
In cases where a patient is to be treated, specific-action antimicrobial substances without general effects are often used. The disadvantage of such treatments is that "typing", a dermination in order to enable choice of the appropriate preparation, must be undertaken before the treatment. Additionally, there is the risk that other microorganisms may invade during treatment against which the preparation has no effect.
On the other hand, if the antimicrobial substance is used as a preservative in the product, it is desirable that it has no effect on the patient, either of an antimicrobial or a toxic nature. The substances that are nowadays used for this purpose are well documented as regards preservative effects but it is also known that many of them exhibit toxic effects in some form or other.
The present invention enables the elimination or at least the drastic reduction of the above shortcomings or disadvantages.
GENERAL DESCRIPTION OF THE INVENTION
In the practice of the invention, it has surprisingly been found that the combination of particular monoglycerides with certain specific groups of chemical substances provides a synergistic effect with regard to antimicrobial properties. In this respect, it has been established that the invention not only provides a synergistic effect in relation to compounds which were previously known to exhibit certain antimicrobial properties, but that it also leads to synergistic effects in relation to chemical substances which had previously not been known to exhibit antimicrobial properties at all.
Aside from the monoglycerides used in accordance with the invention being tolerated particularly well by humans, especially due to their near relationship to substances naturally occuring in the body, many of the substances with which the monoglycerides are combined in accordance with the invention are of a type which does not give rise to any toxic effects in humans. Accordingly, the present invention opens unsuspected possibilities to produce new preparations of a medically active character as well as a preservative character and which do not give rise to any side-effects. Through The synergistic effect of the invention, it additionally becomes possible to use the "active" component in a lower concentration than previously or to use an "active" component which has previously been out of the question altogether, which can also be an advantage from a non-toxicity viewpoint. Furthermore, the new combination in accordance with the invention has proven to give rise to antimicrobial properties of a very general character and therefore even the abovementioned disadvantages with typing and very specific-action antimicrobial properties can be eliminated or reduced.
Other advantages of the invention should be apparent to the man skilled in the art after reviewing the following more detailed description of the invention.
The antimicrobial composition in accordance with the present invention is more particularly distinguished in that it comprises an antimicrobial
REFERENCES:
patent: 3772446 (1973-11-01), Larsson
patent: 4067997 (1978-01-01), Cardin et al.
patent: 4847088 (1989-07-01), Blank
"Food Preservative Composition", STN International, File CA, Chemical Abstracts, vol. 99, No. 19, 7 Nov. 1983, Takeda Chemical Industries, Ltd., Abstract 157083w, & JP 58111669, 2 Jul. 1983.
"Food Preservative Composition", STN International, File CA, Chemical Abstracts, vol. 92, No. 7, 18 Feb. 1980, Isao Shibasaki et al., Abstract 57080w, & JP 54034061, 24 Oct. 1979.
"Antimicrobial Agents Derived from Fatty Acids", John J. Kabara, JAOCS, vol. 61, No. 2, Feb. 1984, pp. 397-403.
Bryland Rickard
L utz Lena-Karin
Lindahl .ANG.ke
Olund Karin
Bioglan AB
Cooney Jr. John M.
Seidleck James J.
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