Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1977-03-16
1989-01-03
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514258, A61K 31505, A61K 3163, A61K 31625
Patent
active
047956399
ABSTRACT:
A composition for testing or treating microbial systems or infections, comprising an effective potentiating amount of a microbial dihydropteridine antagonist, which itself inhibits hydroxymethyldihydropteridine pyrophospokinase and has a sufficiently low toxicity, in combination with an effective amount of a competitor of para-aminobenzoic acid or an inhibitor of dihydrofolate reductase or both, its method of preparation, and its use in the inhibition of the production of dihydrofolic acid by microorganisms under in vivo or in vitro conditions.
REFERENCES:
patent: 2909522 (1959-10-01), Hitchings et al.
patent: 3635978 (1972-01-01), Wood et al.
Burchall James J.
Bushby Stanley R. M.
Cullen Robert
Dunkley Michael J. W.
Ferone Robert
Brown Donald
Burroughs Wellcome Co.
Goldberg Jerome D.
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