Potent peptide for stimulation of cytotoxic T lymphocytes specif

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241841, 4242041, 4242081, 4351723, 4352351, 530326, A61K 3921, A61K 3938, A61K 3912, C12N 1500

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active

059765410

ABSTRACT:
Peptides having high activity in the eliciting of a cytotoxic T lymphocyte response to the HIV-1 envelope glycoprotein gpl60 are described. The activation of 12-15 residue peptides by proteolytic degradation to shorter peptides is shown as are general techniques for characterizing such activation processes.

REFERENCES:
patent: 5013548 (1991-05-01), Haynes et al.
patent: 5019387 (1991-05-01), Haynes et al.
patent: 5562905 (1996-10-01), Kenealy et al.
"Serum angiotensin-1 converting enzyme . . . by major Histocompability Complex Class I molecules", S. Kozlowski et al, Journal of Experimental Medicine, vol. 175, No. 6, Jun. '92, pp. 1417-1422.
"A unique subunit immunogen . . . CD8-positive CTLs", H. Takahashi et al, Vaccines 91, 1991, Cold Spring harbor Laboratory, pp. 1-7.
"Induction of cytotoxic T cells to HIV proteins", J. Berzofsky et al, Aids Research and Human Retroviruses, vol. 7, No. 2, Feb. 1991, p. 144.
"An immunodominant class I-restricted . . . class II-restricted help for itself", H. Takahashi et al., Journal of Experimental Medicine, vol. 171, No. 2, Feb. 1990, pp. 571-576.
"A component of fetal calf . . . into its active form", S. Kozlowski et al, Journal of Cellular Biochemistry, No. 16D, Mar. 1992, p. 66.
Berzofsky et al., "Method to Induce Cytotoxic T Lymphocytes Specific for a Broad Array of HIV-1 Isolates Using Hybrid Synthetic Peptides", Gov't of the USA, Dept. of Health and Human Services, Sep. 18, 1991.
Takahashi et al, The Journal of Exp. Med., vol. 170, pp. 2023-2035 (1989).
Fundamental Immunology, Second Edition, Edited by Williams E. Paul, M.D., Raven Press Ltd., New York (1989).
Benjamin et al, Ann. Rev. Immunol., 2:67-101 (1984).
Kast et al, J. Exp. Med., 164:723-738 (1986).
Chakrabarti et al, Nature, 320:535-537 (1986).
Bennink et al, Nature, 311:578-579 (1984).
Houghten, Proc. Natl. Acad. Sci. USA, 82:5131-5135 (1985).
Takahashi, H. et al., Science, 246:118-121, 1989.
Cease, et al., Proc. Natl. Acad. Sci., U.S.A., 84; 4249-4253, Jun. 1987.
Ratner, et al., Nature, 313; 277-284, Jan. 1985.
De Lisi, et al., Proc. Natl. Acad. Sci., U.S.A., 82; 7048-7052, Oct. 1985.
Happ, et al., Proc. Natl. Acad. Sci., USA, 78(6); 3824-3828, Jun. 1981.
Hopp, J. of Immunological Methods; 88; 1-18; 1986.
Chau, et al., Biochem., 13(2); 211-221, Jan. 1974.
Chou, et al., Ann. Rev. Biochem., 47; 251-76; 1978.
Kozlowsky et al, Keystone Symposium on Antigen Presentation: Function of the MHC. TAOS NM Mar. 5-11, 1992. 66. Abstract.
Takahashi et al, "In Immunodominant epitopes of the (HIV)(env) Glyoprotein gp160 recognized by Class I(MHC) Molecule-restordel Murine (CTL)." PNAS. 85, pp. 3105-3108, May 1988.
Fultz, PN et al "Infection of Non-Human Primates with Human and Simian Immunodefiency Viruses" AIDS Vaccine Research and Clincial Trials. Putney SD et al Editors NY 1990 p. 339-49 abstract.
Hilleman, M.R. "Conclusions: In Pursut of an AIDS Viruses Vaccine" Abstract, Immunol Ser. 44:605-20, 1989.
Echberg, J.W. "Experience with 13 HIV Efficieny trials in Chimpanzees" Int Confon AIDS Jun. 20-23, 1990, 6(1) p. 204, Abstract Th.A.338.
Fauci, A.S. et al "Development and Evaluation of a Vaccine for HIV Infection" Ann. Int Med. May 1, 1989, 110(5) pp. 373-385.

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