Potent inhibitors of human 9-cis retinol dehydrogenase

Details Potent inhibitors of human 9-cis retinol dehydrogenase Potent inhibitors of human 9-cis retinol dehydrogenase

2007-03-06

2007-03-06

Achutamurthy, P. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S004000, C435S006120, C435S252300, C435S320100, C435S069100, C435S071100, C435S440000, C435S026000, C536S023200, C536S023500

Reexamination Certificate

active

09539984

ABSTRACT:
The cDNA sequence of the human 9-cis-retinol dehydrogenase enzyme is disclosed.

REFERENCES:
patent: 5731195 (1998-03-01), Simon et al.
patent: WO 95/34580 (1995-12-01), None
Sequence Search Result.
Seidman. Curent Protocols in Molecular Biology (1994) 6.0.3-6.0.5.
Sequence Alignment.
Blaner, W. S. and Olson, J.A. (1994) The Retinoids, Biology, Chemistry, and Medicine (Sporn, M.B. et al., eds.), 229-255, Raven Press, New York.
Boerman, M.H. E. M. and Napoli, J. L. (1995) “Effects Of Sulfhydryl Reagents, Retinoids, and Solubilization On The Activity Of Microsomal Retinol Dehydrogenase,”Arch. Biochem Biophys.321:434-441.
Boerman, M. H. E. M. and Napoli, J. L. (1995) “Characterization Of A Microsomal Retinol Dehydrogenase: A Short-Chain Alcohol Dehydrogenase With Integral And Peripheral Membrane Forms That Interacts With Holo-CRBP (Type I),” Biochemistry 34:7027-7037.
Boleda, M. D. et al. (1993) “Physiological Substrates For Alcohol Dehydrogense Classes: Aldehydes Of Lipid Peroxidation ω-Hydroxyfatty Acids, And Retinoids,”Arch. Biochem. Biophys.307:85-90.
Chai, X. et al. (1995) “Cloning Of A cDNA For A Second Retinol Dehydrogenase Type II,”J. Biol. Chem.270:28408-28412.
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Labrecque, J. et al. (1993) “Purification and Partial Characterization of a Rat Kidney Aldehyde Dehydrogenase that Oxidizes Retinal to Retinoic Acid,”Biochem. Cell Biol.71: 85-89.
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Mertz, et al. (1997) “Identification and Characterization of A Sterospecific Human Enzyme That Catalyzes 9-cis-Retinol Oxidation,”J. Biol. Chem.272 (18) :11744-11749.
Napoli, J. (1996) “Retinoic Acid Biosynthesis and Metabolism,”FASEB J.10:993-1001.
Romert et al. (1998) “The Identificationof a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway synthesis of 9-cis retinol c acid,” Proceedings National Academy of Sciences USA. 95:4404-4409.
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Ang, H.L. et al. (1996)J. Biol. Chem.271:9526-9534.
Chai, X. and Napoli, J.L. (1996)Gene(Amst.) 169:219-222.

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