Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1990-05-14
1992-12-29
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
562621, 562622, A61K 31185, C07C25910
Patent
active
051751917
ABSTRACT:
The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound.
The invention also concerns a method of selectively inducing termini differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effect to selectively induce terminal differentiation.
Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity.
Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.
REFERENCES:
Hynes, John B. "Hydroxylamine derivatives as potential antimalarial agents" CA 74:22521a, 1971.
Breslow Ronald
Jursic Branko
Marks Paul A.
Rifkind Richard A.
Arnold Craig J.
Bembenick Brian
Raymond Richard L.
Sloan-Kettering Institute for Cancer Research
The Trustees of Columbia University Institute for Cancer Researc
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