Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1994-04-04
1999-08-03
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514544, 514551, 514563, 514615, 514616, 560 8, 560115, 560157, 560159, 560160, 562434, 562450, 562555, 562560, 564156, 564157, 564158, 564159, A61K 3138, C07C23300, C07C23900, C07C22900
Patent
active
059326166
ABSTRACT:
The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8.
The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
REFERENCES:
patent: 2279560 (1942-04-01), Dietrich
patent: 2279973 (1942-04-01), Dietrich
patent: 2346665 (1944-04-01), Cupery
patent: 2895991 (1959-07-01), Randall et al.
patent: 3450673 (1969-06-01), McKillip
patent: 3632783 (1972-01-01), Stonis
patent: 3875301 (1975-04-01), Windheuser
patent: 4442305 (1984-04-01), Weitl et al.
patent: 4614815 (1986-09-01), Cognigni et al.
patent: 4801748 (1989-01-01), Murahashi et al.
patent: 4863967 (1989-09-01), Hall et al.
patent: 4882346 (1989-11-01), Driscoll et al.
patent: 5055608 (1991-10-01), Marks et al.
patent: 5175191 (1992-12-01), Marks et al.
Chemical Abstract vol. 125 No. 222,822, "Iwata et al.," Polyurethanes with mall permanent compression strain and then molding 1996.
Hozumi et al, Jol. Canen, vol. 23, pp. 119-122 (1979) Induction of Erythroid Differentiation in Marine Erythroleukemia cell sby established Polymehtylene Piroids.
Marks et al., Proc. Natl. Acad. Sci., vol. 86, pp. 6358-6362 (Aug. 1989).
Chun et al., Cancer Treatment Reports, vol. 70, pp. 991-996 (Aug. 1986).
Reuben et al., J. Biolog. Chem., vol. 253, pp. 4214-4218 (Jun. 1978).
Tanaka et al., Proc. Natl. Acad. Sci. (USA), vol. 72, pp. 1003-1006 (Mar. 1975).
Fibach et al., Cancer Research, vol. 37, pp. 440-444 (Feb. 1977).
Melloni et a., Chem. Abs., vol. 109, No. 47737e (1988).
Hozumi et al., Int. J. Cancer, vol. 23, pp. 119-122 (1979).
Haces et al., J. Med. Chem., vol. 30, pp. 405-409 (1987).
Das et al., Chem. Abs., vol. 101, No. 54665t (1984).
Brown et al., Chem. Abs., vol. 105, No. 78501v (1986).
Hynes, J. Med. Chem., vol. 13, No. 6, pp. 1235-1237 (1971).
Tabernero et al., Chem. Abs., vol. 98, No. 191329v (1983).
Morrison and Boyd, Organic Chemistry (3rd ed. Allyn and Bacon Boston) (1973) p. 755.
Weitl et al., J. Org. Chem., vol. 46, pp. 5234-5237 (1981).
Breslow Ronald
Jursic Branko
Marks Paul A.
Rifkind Richard A.
Covington Raymond
Kight John
Sloan-Kettering Institute for Cancer Research
The Trustees of Columbia Univerisity in the City of New York
White John P.
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