Organic compounds -- part of the class 532-570 series – Organic compounds – Hydroxamic acids – chalcogen analogs or salts thereof
Patent
1995-04-17
1997-03-04
Clardy, S. Mark
Organic compounds -- part of the class 532-570 series
Organic compounds
Hydroxamic acids, chalcogen analogs or salts thereof
562622, 562623, 564156, 564160, C07C25906, C07C25910, A61K 3119
Patent
active
056081081
ABSTRACT:
The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound.
The invention also concents a method of selectively inducing termini differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effect to selectively induce terminal differentiation.
Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity.
Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.
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Hynes, "Hydroxylamine derivatives as potential antimalarial agents", J. Med. Chem., 1970, 13(6), 1235-7.
CA98:191329, Tabernero et al, "Antitrypanosomal (T. venezuelense) and antimycotic effect . . . ", Acta Cient. Venez. (1981) 32(5), 411-416.
Breslow Ronald
Jursic Branko
Marks Paul A.
Rifkind Richard A.
Bembenick B.
Clardy S. Mark
Sloan-Kettering Institute for Cancer Research
The Trustees of Columbia Univeristy in the City of New York
White John P.
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