Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-06-07
1998-06-30
Clardy, S. Mark
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564153, A61K 31165, C07C23574
Patent
active
057734747
ABSTRACT:
The invention provides a class of compounds and compositions thereof having the structure: ##STR1## wherein A is: ##STR2## The invention also concerns a method of selectively inducing terminal differentiation of neoplastic cells thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable conditions with an amount of the compound to selectively induce terminal differentiation. It also provides a method of treating a patient having a tumor characterized by proliferatoin of neoplastic cells comprising administration of an amount of the compound effective to inhibit proliferation and suppress oncogenicity of neoplastic cells.
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patent: 5608108 (1997-03-01), Marks et al.
Reuben, Robera C., et al., A New Group of Potent Inducers Of Differentiation in Murine Erythroleukemia Cells. Proc. Natl. Academy Sci. USA (1976) 73(3): 862-866.
Morrison, R.T. and Boyd, R.N., Organic Chemistry (3rd ed. Allyn and Bacon) (Boston) (1973) p. 755.
Reuben, R. C., et al., Inducers of Erythroleukemic Differentiation J. Biol. Chem. (1978) 253 (12): 4214-4218.
Tanaka, M., et al., Induction of Erythroid Differentation in Murine Virus Infected Erythroleukemia Cells by Highly Polar Compounds. Proc. Natl. Acad. Sci. USA (1975) 72(3) : 1003-1006.
Breslow Ronald
Marks Paul A.
Rifkind Richard A.
Clardy S. Mark
The Trustees of Columbia University in The City of New York and
White John P.
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