Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-06-07
1997-09-16
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 3116
Patent
active
056681798
ABSTRACT:
##STR1## wherein each of R, R.sub.1, and R.sub.4 is a hydrogen atom or a methyl, ethyl or propyl group, R and R.sub.1 are the same and R and R.sub.4 are the same or different; and wherein y is 4, 5, 6 or 7.
The invention also concerns a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effect to selectively induce terminal differentiation.
Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity.
Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.
REFERENCES:
patent: 4801748 (1989-01-01), Murahashi
Morrison, R.T. and Boyd, R. N., Organic Chemistry (3rd ed. Allyn and Bacon) (Boston) (1973) p. 755.
Reuben, R. C., et al., Inducers of Erythroleukemic Differentiation. J. Biol. Chem. (1978) 253 (12): 4214-4218.
Tanaka, M., et al., Induction of Erythroid Differentiation in Murine Virus Infected Erythroleukemia Cells by Highly Polar Compounds. Proc. Natl. Acad. Sci. USA (1975) 72(3) : 1003-1006.
Reuben,Roberta C., et al., A New Group of Potent Inducers Of Differentiation in Murine Erythroleukemia Cells. Proc. Natl. Acad. Sci. USA (1976) 73(3): 862-866.
Breslow Ronald
Marks Paul A.
Rifkind Richard A.
Bembenick B.
Dees Jos,e G.
Sloan-Kettering Institute for Cancer Research
The Trustees of Columbia University in the City of New York
White John P.
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