Potent immunostimulants from microalgae

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S055100, C536S127000, C536S123000, C536S123100, C536S124000

Reexamination Certificate

active

10332323

ABSTRACT:
Immunostimulatory polysaccharides can be preferentially extracted from food-grade microalgae using an aqueous ethanol extraction procedure. The resulting preparations exhibit extremely potent immunostimulatory activity. The preferential extraction of these immunostimulatory polysaccharides is dependent on the concentration of ethanol used and the extraction temperature. The most efficient conditions are 50% ethanol concentration at temperatures between 60° and 70° C. The isolated polysaccharide preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function.

REFERENCES:
patent: 3462412 (1969-08-01), Yamada et al.
patent: 4511559 (1985-04-01), Szendrei et al.
patent: 4533548 (1985-08-01), Umezawa et al.
patent: 4786496 (1988-11-01), Watanabe et al.
patent: 4822612 (1989-04-01), Shinpo
patent: 4831020 (1989-05-01), Watanabe et al.
patent: 5089481 (1992-02-01), Muto et al.
patent: 5385832 (1995-01-01), Tuse et al.
patent: 5585365 (1996-12-01), Hayashi et al.
patent: 6207652 (2001-03-01), Sakai et al.
Jensen et al., Consumption of Aphanizomenon flos-aque has Rapid Effects on the Circulation and Function of Immune Cells in Humans, JANA 2000 vol. 2, No. 3, pp. 50-58.
Kay, R.A., Microalgae as Food and Supplement. Crit. Rev. Food Sci. Nutr. 1991 30(6)., pp. 555-573.
Elsohly et al. U.S. Appl. No. 10/332,408, filed Aug. 13, 2003.
ImmunosImmunostimulants—John W. Hadden, Immunology Today, vol. 14, No. 6 1993 pp. 275-280.
Immunomodulatory agents for prophylasix and therapy of infections—K. N. Masihi, International Journal of Antimicrobial Agents, pp. 181-191.
Immunotherapy and Cytokines—Kent R. Van Kampen, Seminars in Veterinary Medicine and Surgery, vol. 12, No. 3 Aug. 1997, pp. 186-192.
Polysaccharides in Pharmacy: Current Applications and Future Concepts—G. Franz—PlantaMedica, Feb. 6, 1989, pp. 493-497.
Immunomodulators—Michael O. Frank and Gerald L. Mandell, Basic Principles in the Diagnosis and Management of Infectious Diseases, pp. 450-458.
Wound healing: the role of marophages—Kathy Wilson, Nursing in Critical Care, vol. 2 1997 pp. 291-296.
The Effect of Acemannam Immunostimulant in Combination with Surgery and Radiation Therapy on Spontaneous Canine and Feline Fibrosarcomas—G. King, K. Yates, P. Greenlee, et al, Journal of the American Animal Hospital Association, pp. 439-447.
KRN7000 as a New Type of Antitumor and Immunostimulatory Drug—T. Natori, et al., Drugs from the Sea, pp. 86-87, Sep./Oct. 1995.
Recent Natural Products Based Drug Development: A Pharmaceutical Industry Perspetive—Yue-Zhong Shu, J. Nat. Prod. 1998, pp. 1053-1071.
Spirulina, the Edible Microorganism, O. Ciferri, Microbiological Reviews, Dec. 1983, pp. 551-578.
The Effects ofChlorella Vulgarisin the Protection of Mice Infected WithListeria Mnocytogenes. Role of Natural Killer Cells—Denise C. M. Dantas, et al, Immunopharmacology and Immunotoxicology 1991—pp. 609-619.
Effect ofChlorella vulgarison bone marrow progenitor cells of mice infected withListeria monocytogenes—Denise C. M. Dantas—Mary L.S. Queiroz, Int'l. Journal of Immunopharmacology 1999 pp. 499-508.
DietarySprulina PlatensisEnhances Humoral and Cell-Mediated Immune Functions in Chickens—M. A. Qureshi et al., Immunopharmocol. Immunotoxical 1996 pp. 465-476.
The Macrophage—a cell for all seasons—N. Morrissette, E. Gold, A. Aderem—Cell Biology May 1999 pp. 199-201.
Evaluation of Chemoprevention of Oral Cancer WithSpirulina fusiformis—B. Mathew et al, Nutrition and Cancer 1995 pp. 197-202.
Consumption ofAphanizomenon flos-aquaeHas Rapid Effects on the Circulation and Function of Immune Cells in Humans—G. S. Jensen, et al, JANA vol. 2 Jan. 2000 pp. 50-58.
A New Type of Biological Response Modifier fromChlorella vulgarisWhich Needs Protein Moiety to Show an Antitumour Activity—K. Noda, et al., Phytotherapy Research vol. 12 1998 pp. 309-319.
A Novel Glycoprotein Obtained fromChlorella vulgarisStrain CK22 Shows Antimetastatic Immunopotentiation—K. Tanaka, Cancer Immunol Immunother 1998 pp. 313-320.
A Water-Soluble Antitumor Glycoprotein FromChlorella vulgaris—K. Noda, et al, Planta Medica 1996 pp. 423-426.
Anti-Tumor-Promoting Glyceroglycolipids from the Green Algae,Chlorella vulgaris—T. Morimoto, et al, Phytochemistry vol. 40 1995, pp. 1433-1437.
Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfate polysaccharide derived from a blue-green alga,Spirulina platensis—T. Mishima, Clin. Exp., Metastasis 1998 pp. 541-550.
Further Purification and Structural Analysis of Calcium Sprulan fromSpirulina plantensis—Jung-Burn Lee, et al, J. Nat. Prod. 1998, pp. 1101-1104.
Tumor-induced immune dysfunction: the macrophage connection—K. D. Elgert, et al, Journal of Leukocyte Biology—Sep. 1998 pp. 275-290.
The role of the macrophage in immune regulation—S. Gordon, Institut Pasteur 1998, pp. 685-788.
Molecular basis of macrophage activation: diversity and its origin—D.O. Adams & T.A. Hamilton, Oxford Press 1993 pp. 74-113.
Signal transduction through NF-kB—M.J. May and S. Ghosh, Feb. 1998, pp. 80-88.
Function and Activiation of NF-kB In the Immune System—P. A. Baeuerle & T. Henkel, Annual Review Inc., 1994 pp. 141-178.
Mechanism of expression and role in transcriptional control of the proto-oncognee NFKB-2/LYT-10, C C. Chang et al, Columbia University Sep. 10, 1993 pp. 923-933.
Isolation and Characterization of Patent Cell Walls and Cell Wall Components—W. S .York et al, Method in Enzymology 1985, pp. 3-41.
A Rapid Permethylation of Glycolipid, and Polysaccharide Catgalyzed by Methylsulfinyl Carbanion in Dimethyl Sulfoxide—S. I. Hakomori, The Journal of Biochemistry 1964, pp. 205-208.
The backbone of the pectic polysaccharide rhamnogalacturonan I is cleaved by an endohydrolase and an endolyase, P. Azadi et al, Oxford University Press, 1995 pp. 783-789.
Monosaccharides—R. J. Sturgeon, Method in Plant Biochemistry vol. 2, 1990.
High-Throughput RT-PCR Analysis of Multiple Transcripts Using a Microplate RNA Isolation Procedure—S. Su, et al BioTechniques Jun. 1997 pp. 185-190.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Potent immunostimulants from microalgae does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Potent immunostimulants from microalgae, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Potent immunostimulants from microalgae will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3759552

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.