Potassium ion channel genes and proteins

Details Potassium ion channel genes and proteins Potassium ion channel genes and proteins

1999-07-12

2000-07-11

Mertz, Prema

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 536 231, 435 671, 4353201, 435325, 4352523, 530350, C12N 1512, C12N 1563, C12N 510, C07K 14705

Patent

active

060874880

ABSTRACT:
Novel genes in the erg subfamily of potassium channel proteins in humans are described. This family of proteins, and the genes encoding the proteins, are implicated in the development of long Q-T syndrome, a rare, but often fatal, cardiac arrhythmia.

REFERENCES:
Shi, W et al. Identification of Two Nervous System Specific Members of the erg Potassium Channel Gene Family. 1997. J. Neuroscience.
Yang, P. et al. Analysis of the human Herg Gene: Intron Localisation and Identification of a Novel Inherited Mutation Associated with Long QT. Aug. 25, 1998. GenBank Accession No. AJ010542.
Shi, W et al. Identification of Two Nervous System Specific Members of the erg Potassium Channel Gene Family. 1997. J. Neuroscience. Dec. 15;17(24):9423-32.
Curran et al. "A Molecular Basis for Cardiac Arrhythmia: HERG Mutations Cause Long QT Syndrome", Cell, 80: 795-803 (1995).
Editorial, "Third and Long (QT)", Nature Genetics, 12(1): 1-2 (1996).
EMHTG DATABASE Accession No. AC002345 Hawkins T.L. et al. Jul. 24, 1997 (Rel. 52, created) XP002092028.
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