Potassium channel opener

Details Potassium channel opener Potassium channel opener

2006-02-14

2009-02-24

Price, Elvis O (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

07495127

ABSTRACT:
A potassium channel opener including a compound (e.g., pimaric acid) represented by the formula [I]:wherein R1, R2, R3, R4, R5, R6and R7are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde, or nitrile; or R4and R5may be bonded to each other to form a ring; or R6and R7may be bonded to each other to form a ring; and all of three bonds represented byare single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof as an effective ingredient.

REFERENCES:
Singh et al., J. Chem. Soc. Perkins Trans. (1994), pp. 3349-3352.
Imaizumi et al., Molecular Pharmacology, vol. 62, pp. 836-846 (2002).
Ohwada et al., Bioorg. Med. Chem. Lett., 13, pp. 3971-3974 (2003).
English translation of the International Preliminary Examination Report in PCT/JP02/04085.
A. Ulubelen et al., “Cardioactive Terpenoids and a new Rearranged Diterpene fromSalvia syriaca,” Planta Medica 66 (200) 627-629.
A. Ulubelen et al., “Cardioactive Terpenoids and a new Rearranged Diterpene fromSalvia syriaca,” Planta Medica 66 (200) 627-629 (2000).

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