Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-10-30
2007-10-30
Kemmerer, Elizabeth (Department: 1649)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
10661629
ABSTRACT:
This invention relates to novel potassium channels and genes encoding these channels. More specifically the invention provides isolated polynucleotides encoding the KCNQ5 potassium channel subunit, cells transformed with these polynucleotides, transgenic animals comprising genetic mutations, and the use of the transformed cells and the transgenic animals for the in vitro and in vivo screening of chemical compounds affecting KCNQ5 subunit containing potassium channels.
REFERENCES:
patent: 6403360 (2002-06-01), Blanar et al.
patent: WO99/07832 (1999-02-01), None
patent: WO99/21875 (1999-05-01), None
patent: WO99/31232 (1999-06-01), None
patent: WO 00/44786 (2000-08-01), None
patent: WO 00/61606 (2000-10-01), None
patent: WO 01/70759 (2001-09-01), None
patent: WO 01/70811 (2001-09-01), None
patent: WO 01/92526 (2001-12-01), None
Castaldo P. et al. Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels, J Neurosci, 2002; 22(2): RC1999, 1-6.
Jentsch TJ. Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev. Neuroscience, 2000; 1: 21-30.
Schwake M. et al. Structural determinants of M-type KCNQ (Kv7) K+ channel assembly. J Neurosci, 2006; 26(14): 3757-3766.
Lerche et al., J. Biol. Chem., Apr. 27, 2000, Abstract (PMID: 10787416).
Schroder et al., J. Biol. Chem., May 17, 2000, Abstract (PMID:10816588).
Kubisch et al., Cell, Feb. 5, 1999. vol. 96, pp. 437-446.
Schroeder et al., Nature, Dec. 17, 1998, vol. 396, pp. 687-690.
Wang et al., Nature Genetics, Jan. 1996, vol. 12, pp. 17-23.
Biervert et al., Science, Jan. 16, 1998, vol. 279, pp. 403-406.
William Tam et al., “Linopirdine A Depolarization-Activated Releaser of Transmitters for Treatment of Dimentia.” Lilly Tang et al. eds., inNeurochemistry in Clinical Application, 1995, pp. 47-56.
Skolnick et al., Trends in Biotech., 18(1) :34-39, 2000.
Jobling et al., Mol. Microbiol., 1991, 5(7) :1755-67.
Sambrook et al., Cold Spring Harbor Labs, 1989, pp. 9.47-9.51 and 11.48-11.49.
Ballard Kimberly A.
Kemmerer Elizabeth
NeuroSearch A/S
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