Potassium channel interacting polypeptides and uses thereof

Details Potassium channel interacting polypeptides and uses thereof Potassium channel interacting polypeptides and uses thereof

2006-05-09

2006-05-09

Murphy, Joseph (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S069100, C435S325000, C435S320100, C435S006120

Reexamination Certificate

active

07041795

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

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