Potassium channel inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S249000, C514S258100, C514S299000, C544S235000, C544S253000, C544S349000, C546S112000

Reexamination Certificate

active

06858610

ABSTRACT:
Compounds as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.

REFERENCES:
patent: 2298443 (1942-10-01), Weissberger
patent: 4422871 (1983-12-01), Schirmer et al.
patent: 4975453 (1990-12-01), Becker et al.
patent: 5006512 (1991-04-01), Ohnishi
patent: 5215985 (1993-06-01), Murphy et al.
patent: 5234947 (1993-08-01), Cherksey
patent: 5242947 (1993-09-01), Cherksey et al.
patent: 5310932 (1994-05-01), Atwal et al.
patent: 5328830 (1994-07-01), Janis et al.
patent: 5356775 (1994-10-01), Herbert et al.
patent: 5401758 (1995-03-01), Atwal et al.
patent: 5401848 (1995-03-01), Atwal
patent: 5451580 (1995-09-01), Murphy et al.
patent: 5453421 (1995-09-01), Atwal et al.
patent: 5486515 (1996-01-01), Brown et al.
patent: 6015822 (2000-01-01), Brendel et al.
patent: 6083986 (2000-07-01), Castel et al.
patent: 6333337 (2001-12-01), Gross et al.
patent: 0 286 278 (1988-10-01), None
patent: 0 317 321 (1989-05-01), None
patent: 0 321 175 (1989-08-01), None
patent: 0 472 053 (1992-02-01), None
patent: 0 488 616 (1992-06-01), None
patent: 0 587 180 (1994-03-01), None
patent: 0 608 858 (1994-08-01), None
patent: 0915087 (1999-05-01), None
patent: WO 9518617 (1995-07-01), None
patent: WO 9526342 (1995-10-01), None
patent: WO 9621640 (1996-07-01), None
patent: WO 9636596 (1996-11-01), None
patent: WO 9725893 (1997-07-01), None
patent: WO 9725983 (1997-07-01), None
patent: WO 9726300 (1997-07-01), None
patent: WO 9804521 (1998-02-01), None
patent: WO 9836749 (1998-08-01), None
patent: WO 9937607 (1999-07-01), None
patent: WO 0012077 (2000-03-01), None
Dialog Web Output, Derwent World Patents Index, Records for: pn=EP 915087, 1999.
International Search Report PCT/US 00/34765, 2000.
Still, et al., “Rapid Chromatographic Technique for Preparative Separation with Moderate Resolution,” J. Org. Chem., vol. 43, No. 14, 1978, 2923-2925.
Castle, et al., “Characterization of 4-Aminopyridne Block of the Transient Outward K+Current in Adult Rat Ventricular Myocytes,” The Journal of Pharmacology And Experimental, vol. 264, No. 3, 1450-1459, 1993.
Deal, et al., “Molecular Physiology of Cardiac Potassium Channels,” Physiological Reviews, vol. 76, No. 1, Jan. 1996, 49-67.
Wang, et al, “Sustained Depolarization-Induced Outward Current in Human Atrial Myocytes, Evidence for a Novel Delayed Rectified K+Current Similar to Kv1.5 Cloned Channel Current,” Circulation Research, vol. 73, No. 6, Dec. 1993, 1061-1076.
Hamill, “Improved Patch-Clamp Techniques for High-Resolution Current Recording from Cells and Cell-Free Membrane Patches,” Pflüger Archiv, (1981) 391:85-100.
Fedida, et al., “Identity of a Novel Delayed Rectifier Current From Human Heart With a Cloned K+Channel Current,” Circulation Research, vol. 73, No. 1, Jul. 1993, 210-216.
Chandy, et al., “Voltage-Gated Potassium Channels Are Required For Human T. Lymphocyte Activation,” J. Exp. Med., vol. 160, Aug. 1984, 369-385.
Sanguinetti, “Modulation of Potassium Channels by Antiarrhythmic and Antihypertensive Drugs,” Hypertension, vol. 19, No. E, Mar. 1992, 228-236.
Lynch, et al., “Therapeutic Potential of modulating Potassium Currents in the Diseased Myocardium,” The FASEB Journal, vol. 6, Aug. 1992, 2952-2960.
Colatsky, et al, “Channel Specificity in Antiarrhythmic Drug Action,” Circulation, vol. 82, No. 6, Dec. 1990, 2235-2242.
Halliwell, “K+Channels in the Central Nervous System,” 348-381, 1988.
Amos, et al. “Differences Between Outward Currents of Human Atrial and Subepicardial Ventricular Myocytes,” Journal of Physiology, (1986), 491.1, 31-50.
Wang, et al., “Effects of Flecanide, Quinidine, and 4-Aminopyridine on Transient Outward and Ultrarapid Delayed Rectifier Currents in Human Atrial Myocytes,” The Journal of Pharmacology and Experimental Therapeutics, vol. 272, No. 1, 184-196, 1995.
Lin, et al., Voltage-gated Potassium Channel Regulate Calcium-dependent Pathways Involved in Human T Lymphocyte Activation, J. Exp. Med., vol. 177, 637-645, 1993.
Kaczorowki, et al., “lymphocyte Ion Channels as a Target for Immunosuppression,” Perspective in Drug Discovery and Design 2 (1994) 233-248.
Leonard, et al., Selective Blockers of voltage-Gated K+Channels Depolarize Human T Lymphocytes: Mechanism of the Antiproliferative Effect of Charybdotoxin, vol. 89, 10094-10098, Nov. 1992.
Doupnik, et al., “The Inward Rectifier Potassium Channel Family,” Current Opinion in Neurobiology, 1995, 5:268-277.
Chandy, et al., “Voltage-Gated Potassium Channel Genes,” Handbook of Receptors and Channels, 1-71, 1995.
Epps et al., Chemistry and Physics of Lipids, 69(1994) pp. 137-150.
Chem. Abs., vol. 104, No. 9 Abs No. 68632 (Mar. 3, 1986).
International Search Report PCT/US97/12559, 1997.

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