Potassium channel inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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08067607

ABSTRACT:
The present invention relates to pyridin-3-yl pyridin-3-amine compounds and derivatives thereof having the structure formula (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

REFERENCES:
patent: 4552886 (1985-11-01), Krumkalns et al.
patent: 6303637 (2001-10-01), Bao et al.
patent: 02/24655 (2002-03-01), None
patent: 2006/014877 (2006-02-01), None
patent: 2006/015159 (2006-02-01), None
Han (Advances in Characterization of Pharmaceutical Hydrates. Trends in Bio/Pharmaceutical Industry, pp. 25-29, Mar. 2006).
Schaefer et al. Failure is not an option: learning from unsuccessful proof-of-concept trials. Drug Discovery Today, 2008, 13 (21/22), 913-916.
Horig et al. Review: From bench to clinic and back: Perspective on the 1st IQPC Translational Research Conference. Journal of Translational MEdicine, 2004, 2(44).
J.G. Cannon Chapter Nineteen in Burger's Medicinal Chemistry and Drug Discovery, Fifth Edition, vol. I: Principes and Practice, Wiley-Interscience, 1995, pp. 783-802.
Bilodeau, Mark T., Potent N-(1,3-Thiazol-2-yl)pyridine-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel, J. Med. Chem., 2004, vol. 47, pp. 6363-6372.
Decher, Niels et al., Molecular Basis for Kv1.5 Channel Block, The Journal of Biological Chemistry, 2004, vol. 279, No. 1, pp. 394-400.
Peukert, Stefan et al., Identification, Synthesis, and Activity of Novel Blockers of the Voltage-Gated Potassium Channel Kv1.5, J. Med. Chem., 2003, vol. 46, pp. 486-498.
Knobloch, Karsten et al., Electrophysiological and antiarrhythmic effects of the novel IKur channel blockers, S9947 and 520951, on left vs. right pig atrium in vivo in comparison with the IKr blockers dofetilide, azimilide, d,I-sotalol and ibutilide, Naunyn-Schmiedeberg's Arch Pharmacol., 2002, vol. 366, pp. 482-487.

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