Potassium channel inhibitors

Details Potassium channel inhibitors Potassium channel inhibitors

2007-01-29

2011-10-04

Habte, Kahsay T (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S333000, C546S255000, C546S256000, C546S264000, C546S266000

Reexamination Certificate

active

08030332

ABSTRACT:
The present invention relates to dipyridin-3-ylmethoxy compounds and derivatives thereof having the structure I useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

REFERENCES:
patent: 6670512 (2003-12-01), Stryker et al.
patent: 2003/0166644 (2003-09-01), Ebdrup et al.
patent: 2004/0073039 (2004-04-01), Kadaba
patent: 2004/0082635 (2004-04-01), Hashimoto et al.
patent: 2004/0259912 (2004-12-01), Matsumoto et al.
patent: 0224655 (2002-03-01), None
Peukert et al., “Identification, Synthesis, and Activity of Novel Blockers of the Voltage-Gated Potassium Channel Kv1.5”, J. Med. Chem., vol. 46, pp. 486-498 (2003).
Knobloch et al., “Electrophysiological and Antiarrhythmic Effects of the Novel IKur Channel Blockers, S9947 and S20951, on Left vs. Right Pig Atrium in Vivo in Comparison with the IKr Blockers Dofetilide, Azimilide, d,I-sotalol and Ibutilide”, Naunyn-Schmiedeberg's Arch Pharmacol., vol. 366, pp. 482-487 (2002).

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