Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-07-25
2009-08-04
Davis, Zinna N (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S256000
Reexamination Certificate
active
07569589
ABSTRACT:
The present invention relates to compounds having the structureuseful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
REFERENCES:
patent: WO 00/25770 (2000-05-01), None
patent: WO 00/25774 (2000-05-01), None
patent: WO 01/00573 (2001-01-01), None
patent: WO 01/25189 (2001-04-01), None
patent: WO 01/51519 (2001-07-01), None
patent: WO 02/24655 (2002-03-01), None
patent: WO 02/44137 (2002-06-01), None
patent: WO 02/46162 (2002-06-01), None
patent: WO 02/48131 (2002-06-01), None
patent: WO 02/100825 (2002-12-01), None
patent: WO 03/059873 (2003-07-01), None
patent: WO 2004/082716 (2004-09-01), None
patent: WO 2004/083157 (2004-09-01), None
patent: WO 2004/098525 (2004-11-01), None
patent: WO 2005/030129 (2005-04-01), None
patent: WO 2005/030130 (2005-04-01), None
patent: WO 2005/030217 (2005-04-01), None
patent: WO 2005/030726 (2005-04-01), None
patent: WO 2005/030727 (2005-04-01), None
patent: WO 2005/030729 (2005-04-01), None
patent: WO 2005/030791 (2005-04-01), None
patent: WO 2005/030792 (2005-04-01), None
Brendel, J. “Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias”. Cardiovascular, Renal, Endocrine & Metabolic 2002, pp. 1589-1598.
R. Haberi, et al., Monatshefte Fuer Chemie, vol. 88, pp. 47-51 (1957) Database Accession No. 1957:71471.
W. Czuba, Bulletin DE L′Academie Polonaise Des Sciences, vol. 8, No. 6, pp. 281-284, 1960.
G.N. Walker, Organic Chemistry, vol. 27, pp. 2966-2967, 1962, Database Accession No. 1025723/BRN.
K.K. Chiu, et al., Chemical Society, Section C, Organic Chemistry, vol. 19, pp. 2758-2761, 1969.
K.K. Chiu, et al., Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 29, No. 11, pp. 1947-1952 (1973).
E.V. Brown, et al.,, “Pinacol Rearrangement of Quinoline Analogs of Benzopinacol and Evidence for Rearrangement . . . ”, Journal of Heterocyclic Chemistry, vol. 6, No. 4, pp. 567-570 (1969).
E.F. Pratt, et al., “Oxidation by Solids. II. The Preparation of Either Tetraarylethanes of Diaryl Ketones by the Oxidation of . . . ”, Journal of Organic Chemistry, vol. 28, pp. 638-642 (1963).
M.R. Kegelman, et al., “The Pinacol Rearrangement in the Heterocyclic Series. I. Pyridine Analogs of Benzopinacol”, Journal of the American Chemical Society, vol. 75, pp. 4649-4651 (1953).
N.D. Heindel, et al., Tetrahedron Letters, No. 32, pp. 3579-3582 (1968).
V.J. Traynelis, et al., “Reactions of 4-Alkylpyridine N-Oxide With Dimethyl Sulfoxide”, Tetrahedron Letters, No. 42, pp. 3619-3622 (1960).
S. Banks, et al., “Substituent Effect on the Electrochemical Oxidation of Arylmethyl Anions. 4. Effect of Pyridine Rings”, Journal of Organic Chemistry, vol. 52, pp. 5105-5111 (1987).
J.J. Eisch, et al., “Coordination-Induced Reductive Elimination and Titanium(II) Carbenoid Transfer in Reactions of”, Organometallics, vol. 22, pp. 24-26 (2003).
M. Abe, et al., “Oxidative Ring-Opening Reaction of Cyclopropanone Acetals with Carbonyl Compounds via Photoinduced Electron Transfer.”, Journal of Organic Chemistry, vol. 60, pp. 3065-3073 (1965).
H.E. Zimmermann, et al., “Control of the Sterochemistru pf Kinetic Protonation: Intramolecular Proton Delivery”, Journal of Organic Chemistry, vol. 64, pp. 6635-6645 (1999).
E.V. Brown, et al., “Photochemical Preparation and Rearrangement of Some Symmetrical Methoxypyridyl Phenyl Glycols (Pinacols)”, Journal of Heterocyclic Chemistry, vol. 8, No. 6, pp. 967-973 (1971).
M.L. Black, et al., “2-(2-Pyridyl)-1,2-diarylalkanols as Hypocholesteremic Agents”, Journal of Medicinal Chemistry, vol. 10, No. 4, pp. 565-575 (1967).
F.J. Villani, et al., “Hypocholesteremic Agents. I. Substituted Stilbazoles and Dihydrostilbazoles”, Journal of Medicinal Chemistry, vol. 13, No. 3, pp. 359-366 (1970).
A. Richardson Jr. et al., “Triarylpyridylethanols and Triarylpyridylethylenes. Chemistry and Antifertility Effects”, Journal of Medicinal Chemistry, vol. 18, No. 7, pp. 689-691 (1975).
D.M. D′Alessandro, et al., Journal of Chemistry, vol. 56, No. 7, pp. 657-664 (2003).
M.R. Kegelman, et al. “The Pinacol Rearrangement in the Heterocyclic Series. III. Numerical Migratory Aptitudes”, Journal of the American Chemical Society, vol. 76, pp. 2711-2713 (1954).
Search Report ROC (Taiwan Patent Application No. 094125011). Date of Completion of Search: Apr. 1, 2009.
J.H. Burckhalter, et al. “2-(2-pyridyl0-1,2-Diarylalkanols as Hypocholesteremic Agents” Journal of Medicinal Chemistry, 1967. vol. 10, No. 4, pp. 565-575. The pertinent section is - The Abstract and the compounds 76-81 on p. 566.
Bergman Jeffrey M.
Bilodeau Mark T.
Dinsmore Christopher J.
Hartnett John
Manley Peter
Daniel Mark R.
Davis Zinna N
Merck & Co. , Inc.
Parr Richard S.
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