Potassium channel inhibitors

Details Potassium channel inhibitors Potassium channel inhibitors

2005-02-22

2005-02-22

Huang, Evelyn Mei (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S299000, C514S310000, C514S313000, C514S243000, C514S249000, C514S260100, C514S258100, C514S357000, C514S400000, C514S256000, C514S365000, C514S397000, C514S602000, C546S143000, C546S159000, C546S160000, C546S112000, C546S337000, C544S235000, C544S253000, C544S356000, C544S349000, C544S183000, C544S335000, C548S338100, C548S204000, C548S315100, C564S084000

Reexamination Certificate

active

06858611

ABSTRACT:
Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.

REFERENCES:
patent: 3953506 (1976-04-01), Spicer et al.
patent: 4005140 (1977-01-01), Spicer et al.
patent: 4975453 (1990-12-01), Becker et al.
patent: 5006512 (1991-04-01), Ohnishi
patent: 5215985 (1993-06-01), Murphy et al.
patent: 5234947 (1993-08-01), Cherksey
patent: 5242947 (1993-09-01), Cherksey et al.
patent: 5310932 (1994-05-01), Atwal et al.
patent: 5328830 (1994-07-01), Janis et al.
patent: 5356775 (1994-10-01), Hebert et al.
patent: 5401758 (1995-03-01), Atwal et al.
patent: 5401848 (1995-03-01), Atwal
patent: 5451580 (1995-09-01), Murphy et al.
patent: 5453421 (1995-09-01), Atwal et al.
patent: 5486515 (1996-01-01), Brown et al.
patent: 6083986 (2000-07-01), Castle et al.
patent: 6333337 (2001-12-01), Gross et al.
patent: 6458794 (2002-10-01), Gross et al.
patent: 0 286 278 (1988-10-01), None
patent: 0 317 321 (1989-05-01), None
patent: 0 321 175 (1989-08-01), None
patent: 0 472 053 (1992-02-01), None
patent: 0 488 616 (1992-06-01), None
patent: 0 587 180 (1994-03-01), None
patent: 0 608 858 (1994-08-01), None
patent: 9518617 (1995-07-01), None
patent: 9526342 (1995-10-01), None
patent: 9621640 (1996-07-01), None
patent: 9636596 (1996-11-01), None
patent: 9725982 (1997-07-01), None
patent: 9725983 (1997-07-01), None
patent: 9726300 (1997-07-01), None
patent: 9804521 (1998-02-01), None
patent: 9836749 (1998-08-01), None
patent: 9937607 (1999-07-01), None
Lumma et al. (1987) J. Med. Chem. 30(5): 755-758).*
Still et al, “Rapid Chromatographic Technique for Preparative Separation with Moderate Resolution,” J. Org. Chem., vol. 43, No. 14, 1978, pp. 2923-2925.
Castle et al., “Characterization of 4-Aminopyridne Block of the Transient Outward K+Current in Adult Rat Ventricular Myocytes,” The Journal of Pharmacology and Experimental, vol. 264, No. 3, pp. 1450-1459.
Deal et al, “Molecular Physiology of Cardiac Potassium Channels,” Physiological Reviews, vol. 76, No. 1, Jan. 1996, pp. 49-67.
Wang et al, “Sustained Depolarization-Induced Outward Current in Human Atrial Myocytes, Evidence for a Novel Delayed Rectified K+Current Similar to Kvl.5 Cloned Channel Current,” Circulation Research, vol. 73, No. 6, Dec. 1993, pp. 1061-1076.
Hamill, “Improved Patch-Clamp Techniques for High-Resolution Current Recording from Cells and Cell-Free Membrane Patches,” Pflüger Archiv, (1981) 391:85-100.
Fedida et al, “Identity of a Novel Delayed Rectifier Current From Human Heart With a Cloned K+Channel Current,” Circulation Research, vol. 73, No. 1, Jul. 1993, pp. 210-216.
Chandy et al., “Voltage-Gated Potassium Channels are Required for Human T Lymphocyte Activation,” J. Exp. Med., vol. 160, Aug. 1984, pp. 369-385.
Sanguinetti, “Modulation of Potassium Channels by Antiarrhythmic and Antihypertensive Drugs,” Hypertension, vol. 19, No. E, Mar. 1992, pp. 228-236.
Lynch et al, “Therapeutic Potential of modulating Potassium, Currents in the Diseased Myocardium,” The FASEB Journal, vol. 6, Aug. 1992, p. 2952-2960.
Colatsky et al, “Channel Specificity in Antiarrhythmic Drug Action,” Circulation, vol. 82, No. 6, Dec. 1990, pp. 2235-2242.
Halliwell, “K+Channels in the Central Nervous System,” pp. 348-381.
Amos et al, “Differences Between Outward Currents of Human Atrial and Subepicardial Ventricular Myocytes,” Journal of Physiology, 1986, 491.1, pp. 31-50.
Wang et al, “Effects of Flecanide, Quinidine, and 4-Aminopyridine on Transient Outward and Ultrarapid Delayed Rectifier Currents in Human Atrial Myocytes,” The Journal of Pharmacology and Experimental Therapeutics, vol. 272, No. 1, pp. 184-196.
Lin et al. “Voltage-gated Potassium Channel Regulate Calcium-dependent Pathways Involved in Human T Lymphocyte Activation,” J. Exp. Med., vol. 177, pp. 637-645.
Kaczorowki et al, “lymphocyte Ion Channels as a Target for Immunosuppression,” Perspective in Drug Discovery and Design 2, 1994, pp. 233-248.
Leonard et al, “Selective Blockers of voltage-Gated K+Channels Depolarize Human T Lymphocytes: Mechanism of the Antiproliferative Effect of Charybdotoxin”, vol. 89, Nov. 1992, pp. 10094-10098.
Doupnik et al, “The Inward Rectifier Potassium Channel Family”, Current Opinion in Neurobiology, 1995, 5:268-277.
Chandy et al, “Voltage-Gated Potassium Channel Genes”, Handbook of Receptors and Channels, 1995, pp. 1-71.
Epps et al., Chemistry and Physics of Lipids, 69, 1994, pp. 137-150.
Chem Abs., vol. 104, No. 9 Abs No. 68632 (Mar. 3, 1986).
International Search Report PCT/US97/12559.
International Search Report PCTUS01/23258.
Robertson et al. J. Med. Chem. vol. 33, No. 6, 1990.

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