Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-07-15
2000-07-04
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514354, 514378, 514448, 514471, 514521, 514439, 514551, 514596, 514597, 514602, 514604, 546314, 546323, 548248, 549 72, 549487, 558404, 560 13, 560255, 564 27, 564 49, 564 84, 564 91, A61K 3117, A61K 3118, A61K 31216, A61K 314155
Patent
active
060839864
ABSTRACT:
Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
REFERENCES:
patent: 2298443 (1942-10-01), Weissberger
patent: 4422871 (1983-12-01), Schirmer et al.
patent: 4975453 (1990-12-01), Becker et al.
patent: 5006512 (1991-04-01), Ohnishi
patent: 5215985 (1993-06-01), Murphy et al.
patent: 5234947 (1993-08-01), Cherksey
patent: 5242947 (1993-09-01), Cherksey et al.
patent: 5310932 (1994-05-01), Atwal et al.
patent: 5328830 (1994-07-01), Janis et al.
patent: 5356775 (1994-10-01), Herbert et al.
patent: 5401758 (1995-03-01), Atwal et al.
patent: 5401848 (1995-03-01), Atwal
patent: 5451580 (1995-09-01), Murphy et al.
patent: 5453421 (1995-09-01), Atwal et al.
patent: 5486515 (1996-01-01), Brown et al.
Still, et al., "Rapid Chromatographic Technique for Preparative Separation with Moderate Resolution," J. Org. Chem., vol. 43, No. 14, 1978, 2923-2925.
Castle, et al., "Characterization of 4-Aminopyridne Block of the Transient Outward K.sup.+ Current in Adult Rat Ventricular Myocytes," The Journal of Pharmacology and Experimental, vol. 264, No. 3, 1450-1459 (1993).
Deal, et al., "Molecular Physiology of Cardiac Potassium Channels," Physiological Reviews, vol. 76, No. 1, Jan. 1996, 49-67.
Wang, et al, "Sustained Depolarization-Induced Outward Current in Human Atrial Myocytes, Evidence for a Novel Delayed Rectified K.sup.+ Current Similar to Kv1.5 Cloned Channel Current," Circulation Research, vol. 73, No. 6, Dec. 1993, 1061-1076.
Hamill, "Improved Patch-Clamp Techniques for High-Resolution Current Recording from Cells and Cell-Free Membrane Patches," Pfluger Archiv, (1981) 391:85-100.
Fedida, et al., "Identity of a Novel Delayed Rectifier Current From Human Heart With a Cloned K.sup.+ Channel Current," Circulation Research, vol. 73, No. 1, Jul. 1993, 210-216.
Chandy, et al., "Voltage-Gated Potassium Channels Are Required For Human T. Lymphocyte Activation," J. Exp. Med., vol. 160, Aug. 1984, 369-385.
Sanguinetti, "Modulation of Potassium Channels by Antiarrhythmic and Antihypertensive Drugs," Hypertension, vol. 19, No. E, Mar. 1992, 228-236.
Lynch, et al., "Therapeutic Potential of modulating Potassium Currents in the Diseased Myocardium," The FASEB Journal, vol. 6, Aug. 1992, 2952-2960.
Colatsky, et al, "Channel Specificity in Antiarrhythmic Drug Action," Circulation, vol. 82, No. 6, Dec. 1990, 2235-2242.
Halliwell, "K.sup.+ Channels in the Central Nervous System," 348-381 (1988).
Amos, et al. "Differences Between Outward Currents of Human Atrial and Subepicardial Ventricular Myocytes," Journal of Physiology, (1986), 491.1, 31-50.
Wang, et al., "Effects of Flecanide, Quinidine, and 4-Aminopyridine on Transient Outward and Ultrarapid Delayed Rectifier Currents in Human Atrial Myocytes," The Journal of Pharmacology and Experiemental Therapeutics, vol. 272, No. 1, 184-196 (1995).
Lin, et al., Voltage-gated Potassium Channel Regulate Calcium-dependent Pathways Involved in Human T Lymphocyte Activation, J. Exp. Med., vol. 177, 637-645 (1993).
Kaczorowki, et al., "lymphocyte Ion Channels as a Target for Immunosuppression," Perspective in Drug Discovery and Design 2 (1994) 233-248.
Leonard, et al., Selective Blockers of voltage-Gated K.sup.+ Channels Depolarize Human T Lymphocytes: Mechanism of the Antiproliferative Effect of Charybdotoxin, vol. 89, 10094-10098, Nov. 1992.
Doupnik, et al., "The Inward Rectifier Potassium Channel Family," Current Opinion in Neurobiology, 1995, 5:268-277.
Chandy, et al., "Voltage-Gated Potassium Channel Genes," Handbook of Receptors and Channels, 1-71 (1995).
Epps et al., Chemistry and Physics of Lipids, 69(1994) pp. 137-150.
WO 95-18617 Abstract (1995).
Chem. Abs., vol. 104, No. 9 Abs No. 68632 (Mar. 3, 1986).
International Search Report PCT/US97/12559 (1997).
Amato George Salvatore
Beaudoin Serge
Castle Neil Alexander
Gross Michael
Hollinshead Sean Patrick
Eli Lilly & Company
ICAgen Inc.
O'Sullivan Peter
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