Post synthesis chemical modification of particle reagents

Details Post synthesis chemical modification of particle reagents Post synthesis chemical modification of particle reagents

1995-08-03

1998-12-29

Chin, Christopher L.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is particulate and the particles are of...

427337, 427338, 428403, 435 71, 435962, 436518, 436531, 436532, 436533, 436815, G01N 33546

Patent

active

058540830

ABSTRACT:
A method is provided for enhancing the stability and increasing the activity of polymer particle reagents by incubating a polymer particle which has been covalently bound to a compound of biological interest, such as a drug, with a modifying agent that will place a negative charge on the surface of the polymer particle and reduce residual functional groups. The modifying agent is preferably an anionic nucleophile selected from the group consisting of .beta.- mercaptoacetic acid and the thiosulfates.

REFERENCES:
patent: 4415700 (1983-11-01), Batz et al.
patent: 4480042 (1984-10-01), Craig et al.

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