Post-partum mammalian placenta, its use and placental stem...

Details Post-partum mammalian placenta, its use and placental stem... Post-partum mammalian placenta, its use and placental stem...

2007-08-14

2007-08-14

Li, Q. Janice (Department: 1633)

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

C424S093100, C424S093700, C435S002000, C435S325000, C435S395000, C435S041000, C435S069100, C435S070100, C435S070300, C435S001100, C435S001200

Reexamination Certificate

active

10640428

ABSTRACT:
The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

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