Post-ischemic myocardial dysfunction using thromboxane A.sub.2 a

Details Post-ischemic myocardial dysfunction using thromboxane A.sub.2 a Post-ischemic myocardial dysfunction using thromboxane A.sub.2 a

1987-09-17

1990-06-05

Lieberman, Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514456, A61K 3134, A61K 31357, G07D30700

Patent

active

049314602

ABSTRACT:
A method is provided for improving post-ischemic myocardial dysfunction such as contractile dysfunction or reperfusion injury by administering a thromboxane A.sub.2 antagonist before, during or immediately after an ischemic attack.

REFERENCES:
patent: 4416896 (1983-11-01), Nakane et al.
patent: 4663336 (1987-05-01), Nakane et al.
Schror, K. et al., "Treatment of Acute Myocardial Ischemia with a Selective Antagonist of Thromboxane Receptors", Br. J. Pharmacol., 1986, 87:631-7.
Ogletree, M. L. et al., "Pharmacological Actions of SQ 29,548 a Novel Thromboxane Antagonist", J. Pharmacol. Ex. Ther., 1985; 234:435-41.
Hoeft, A. et al., "Preservation of Myocardium in Transient Ischemia by the Thromboxane Synthetase Inhibitor," UK-38,485, Res. Exp. Med., 1986; 186:35-46.
Schmitz, J. M. et al., "Vascular Prostaglandin and Thromboxane Production in a Canine Model of Myocardial Ischemia," Circ. Res., 1985, 57:223-31.
Michael, L. H. et al., "Myocardial Ischemia: Platelet and Thromboxane Concentrations in Cardiac Lymph and the Effects of Ibuprofen and Prostacyclin," Cir. Res., 1986; 59:49-55.
Grover, G. J. et al., "Effect of the Thromboxane Receptor Antagonist SQ 29,548 on Infarct Size in Dogs," Circulation, 1986; 74 (Suppl II): 348 (Abstract).
Pagani, M. et al., "Initial Myocardial Adjustments to Brief Periods of Ischemia and Reperfusion in the Conscious Dogs," Circ. Res., 1978; 43:83-92.

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