Positive selection of serum proteins for proteomic analysis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S002000, C435S007100, C436S501000, C436S518000, C436S522000, C422S050000

Reexamination Certificate

active

07955810

ABSTRACT:
This invention relates to methods and kits for positive selection of species of interest based on peptide/protein sequence from a biological sample. The species of interest may be proteins and/or peptides of interest which may be placed through a mass spectrometer to obtain a blood peptide/protein signature. The blood peptide/protein signature may be used in proteomic analysis. The techniques include but are not limited to the use of collectors comprising nucleic acid molecules to extract a composition that has a lower concentration of a high abundance species of interest from a sample. This limits the level of influence that any collectors species may have on the results of a mass spectra.

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Anderson, N.L., The roles of multiple proteomic platforms in a pipeline for new diagnostics, Molecular & Cellular Proteomics, 2007, 4.10, pp. 1441-1444.
Anderson, N. L. et al., Mass spectrometric quantitation of peptides and proteins using stable isotope standards and capture by anti-peptide antibodies (SISCAPA), Journal of Proteome Research, 2004, 3:235-244.
Faca, V. et al., Contribution of protein fractionation to depth of analysis of the serum and plasma proteomes, Journal of Proteome Research, 2007, pp. A-G.
Tang, H. et al., A novel four-dimensional strategy combining protein and peptide separation methods enables detection of low-abundance proteins in human plasma and serum proteomes, Proteomics, 2005, 5:3329-3342.
Zolotarjova, N. et al., Removal and depletion of high-abundance proteins from biological fluids, LCGC North America, Feb. 2007, 25:2, pp. 118-140.

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