Positive modulators of nicotinic receptor agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S492000

Reexamination Certificate

active

07402604

ABSTRACT:
Compounds according to formula I:wherein R1, W, R2, R3, X, R4and R5are as described in the specification, enantiomers thereof, pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.

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Phytochemistry, vol. 11, 1972, Torigoe, et al. “Cytokinin Activity of Azaindene . . . and Indole Derivatives”, pp. 1623-1630, see cmpds (XIII & (XIV), p. 1625.
Chem Abstracts, vol. 57, (Columbus, Ohio, USA), Piers et al. “The Synthesis of Mercaptoindoles”, Abst No. 15053h, Can. J. Chem. 1962, 40, 511-517.
Goodman & Gilman's , “The Pharmaceutical Basis of Therapeutics,” 10th Edition, 2001, p. 549.

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