Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1993-09-28
1996-01-09
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4352351, 4352402, 4353201, C12N 1563, C12N 1586, C12N 701, C12N 510
Patent
active
054828538
ABSTRACT:
The present invention provides vectors for the efficient and position-specific integration of expressible, exogenous nucleotide sequences into cellular genomes. This invention takes advantage of the discovery of a position-specific endonuclease and position-specific insertion markers for the design of said vectors. In addition, a gene comprising a recombinant nucleic acid molecule encoding a polypeptide possessing the biological activity of a position-specific endonuclease, wherein the biological activity of said endonuclease is the catalysis of position-specific insertion of genetic material carried between the position-specific integration markers, is disclosed.
REFERENCES:
patent: 4405712 (1983-09-01), Vande Wooude et al.
patent: 4738922 (1988-04-01), Haseltine et al.
patent: 5292662 (1994-03-01), Sandmeyer
Mann, Richard, et al., "Construction of a Retrovirus Packaging Mutant and Its Use to Produce Helper-Free Defective Retrovirus." Cell 33:153-159 (1985).
Miller, A. Dusty et al., "Redesign of Retrovirus Packaging Cell Lines to Avoid Recombination Leading to Helper Virus Production." Mole. & Cell. Biol. 6:2895-2902 (1986).
Eglitis, Martin, et al., "Gene Expression in Mice After High Efficiency Retroviral-Mediated Gene Transfer." Science. 230:1395-1398 (1985).
Clark Doni J. et al., "A Yeast Sigma Composite Element, TY3, Has Properties of a Retrotransposon." J. Biol. Chem. 263:1413-1423 (1988).
Feng, Da-Fei, et al., "Progressive Sequence Alignment as a Prerequisite to Correct Phylogenetic Trees." J. Mole. Evol. 25:351-360 (1987).
Ito, Hisao, et al., "Transformation of Intact Yeast Cells Treated with Alkali Cations." J. Bacteriology. 153:163-168 (1983).
Boeke, Jef D. et al., "Ty Elements Transpose Through an RNA Intermediate." Cell. 40:491-500 (1985).
Huang, Anthony, et al., "Monoclonal Antibody Covalently Coupled with Fatty Acid: A Reagent for in Vitro Liposome Targeting." J. Biol. Chem. 255:8015-8018 (1980).
Misra, Tapan K. et al., "Avian Retrovirus pp32 DNA-Binding Protein: I. Recognition of Specific Sequences on Retro Virus DNA Terminal Repeats." J. Virol. 44:340-353 (1982).
Grandgenett, Duane P. et al., "Nuclease Mechanism of the Avian Retrovirus pp32 Endonuclease." J. Virol. 48:970-974 (1986).
Ausubel, "Oligonucleotide-Directed Mutagenesis without Phenotypic Selection." Basic Protocol. Units 8.1-8.3:8.1.1-8.3.3 (1987)
Shinnick, Thomas M. et al., "Nucleotide Sequence of Moloney Murine Leukaemia Virus." Nature 293:543-548 (1981).
Miller A. Dusty, et al., "Generation of Helper-Free Amphotropic Retroviruses that Transduce a Dominant-Acting, Methotrexate-Resistant Dihydrofolate Reductase Gene." Mole. Cell. Biol. 5:431-437 (1985).
Cone, Roger D. et al., "High-Efficency Gene Transfer into Mammalian Cells: Generation of Helper-Free Recombinant Retrovirus with Broad Mammalian Host Range." Proc. Natl. Acad. Sci. USA. 81:6349-6353 (1984).
Sandmeyer, Suzanne B. "Sigma Elements are Position-Specific for Many Different Yeast tRNA Genes." Nucl. Acid. Res. 16:1499-1515 (1988).
Shih Chu-Chih, et al., "Highly Preferred Targets for Retrovirus Integration." Cell 53:531-537 (1988).
Adams, Sally E. et al., "The Expression of Hybrid HIV: Ty Virus-like Particles in Yeast." Nature 329:68-70 (1987).
Eglitis, Martin A. "Retroviral Vectors for Introduction of Genes into Mammmalian Cells." BioTech. 6:608-614 (1988).
Fink, Gerald F. et al., "The Mechanism and Consequences of Retrotransposition." Review TIG 118-123 (1986).
Terry, Robert, et al., "Properties of Avian Sarcoma-Leukosis Virus pp32-Related Pol-Endonucleases Produce in Escherichia coli." J. Virol. 62:2358-2365 (1988).
Chodosh, Lewis A. et al., "A Yeast and a Human CCAAT-Binding Protein Have Heterologous Subunits That are Functionally Interchangeable." Cell 53:25-35 (1988).
Hansen, Lori J. et al., "Ty3 A Yeast Retrotransposon Associated with tRNA Genes, Has Homology to Animal Retroviruses."Mol. Cell. Biol. 8:5245-5256 (1988).
Youngren, Susan D. et al., "Functional Organization of the Retrotransposon Ty from Saccharomyces Cerevisiae: Ty Protease is Required for Transportation." Mol. Cell. Biol. 8:1421-1431 (1988).
Mranyi, W. et al., "Nucleotide Sequence of a Human Retrotransposon Region Encoding a Reserve Transcriptase-like Protein." Nucl. Acids. Res. 16:7724 (1988).
Fulton, A. M. et al., "Upstream and Downstreem Transcriptional Control Signals in the Yeast Retrotransposon Ty." Nucl. Acids. Res. 16:5439-5459 (1988).
Malim, Michael H. et al., "The Production of Hybrid Ty: IFN Virus-like Particles in Yeast." Nucl. Acids. Res. 15:7571-7580 (1987).
Coney, Leslie R. et al., "Control of Yeast Gene Expression by Transpousable Elements: Maximum Expression Requires a Functional Ty Activator Sequence and a Defective Ty Promotor." Mol. Cell. Biol. 8:4009-4017 (1988).
Jacobs, E. et al., "Retrovirus-like Vectors for Saccharomyces cervisiae: Integration of Foreign Genes Controlled by Efficient Promoters into Yeast Chromosomal DNA." Gene 67:259-269 (1988).
Iida, Hidetoshi, "Multistress Resistance of Saccharomyces cerevisiae is Generated by Insertion of Retrotransposon Ty into the 5' Coding Region of the Adenylate Cyclase Gene." Mol. Cell. Biol. 8:5555-5560 (1988).
Eichinger, Daniel, et al. "The DNA Intermediate in Yeast Ty 1 Element Transposition Copurifies with Virus-like Particles: Cell-Free Ty 1 Transposition." Cell 54:955-966 (1988).
Holmes, David S. and Quigley, Michael "A Rapid Boiling Method for the Preparation of Bacterial Plasmids." Anal. Biochem. 114:193-197 (1981).
Carter Philip W.
Schwartz Richard A.
The Regents of the University of California
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