Position-specific insertion vectors and method of using same

Details Position-specific insertion vectors and method of using same Position-specific insertion vectors and method of using same

1992-06-08

1994-03-08

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Vector, per se

536 231, 536 232, C12N 1585, C12N 1552, C12N 1511

Patent

active

052926621

ABSTRACT:
The present invention provides vectors for the efficient and position-specific integration of expressible, exogenous nucleotide sequences into cellular genomes. This invention takes advantage of the discovery of a position-specific endonuclease and position-specific insertion markers for the design of said vectors. In addition, a gene comprising a recombinant nucleic acid molecule encoding a polypeptide possessing the biological activity of a position-specific endonuclease, wherein the biological activity of said endonuclease is the catalysis of position-specific insertion of genetic material carried between the position-specific integration markers, is disclosed.

REFERENCES:
Mann et al. (1983), Cell 33: 153-159.
Jacobs et al. (1988, Gene 67: 259-269.
Clark et al. (1988), J. Biol. Chem. 263(3): 1413-1423.

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