Portable COHB analyzer

Chemistry: physical processes – Physical processes – Crystallization

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23913, 422 68, 356 40, G01N 3372

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active

043245560

ABSTRACT:
A portable spectrophotometric apparatus and method therefor for measuring the percentage of carboxyhemoglobin (COHb) in blood. The apparatus comprises a spectrophotometer and wavelength selection filters for testing a reference sample having a hemolizing agent and sodium hyposulfite and a treated blood sample with the hemolizing agent and sodium hyposulfite and providing a two component COHb-Hb system for determining relative absorbance values of the two samples at light wavelengths of 420 nanometers and 432 nanometers, the wavelengths corresponding to respective peak absorbance of the components in the high absorbance Soret region on opposite sides of an isobestic point formed by the intersection of their respective absorbance-wavelength curves. The ratio of the derived relative values is compared against predetermined data to determine the percentage of carboxyhemoglobin in the blood.

REFERENCES:
patent: 3994585 (1976-11-01), Frey
patent: 4003662 (1977-01-01), Retzer et al.
Collision et al., Clinical Chemistry, vol. 14, #2, pp. 162-171.
Klendshoj et al., 183 Journal of Biological Chemistry, p. 297 (1950).
4,134,678 01001979 Brown et al. 356 40
"Gradwohls' Clinical Laboratory Methods and Diagnosis", Frankel et al., v I, The C. V. Mosby Co., St. Louis, MO, 1970.
Commins et al., 22 British Journal of Industrial Medicine 139 (1945).
Small et al., 31 Journal of Applied Physiology, p. 154, 1971.
Rodney et al., Clinical Chemistry, 1388-1393, 1979.

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