Porphyrins for boron neutron capture therapy

Details Porphyrins for boron neutron capture therapy Porphyrins for boron neutron capture therapy

1989-05-26

1990-09-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

540145, A61K 3169, C07F 505

Patent

active

049593560

ABSTRACT:
Novel compounds for treatment of brain tumors in Boron Neutron Capture Therapy are disclosed. A method for preparing the compounds as well as pharmaceutical compositions containing said compounds are also disclosed. The compounds are water soluble, non-toxic and non-labile boronated porphyrins which show significant uptake and retention in tumors.

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BNL Report 41098, Miura et al., "Synthesis of New Boron Containing Porphyrins and Their In Vivo Properties", presented at the 3rd International Symposium on Neutron Capture Therapy, Bremen, West Germany, May 31-Jun. 3, 1988.
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Ponomareo et al., Chemical Abstracts, vol. 84 (1976) 1055596.

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