Porphyrins and cancer treatment

Details Porphyrins and cancer treatment Porphyrins and cancer treatment

1990-11-26

1992-11-10

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48722

Patent

active

051625199

ABSTRACT:
This invention provides novel compounds for therapy of tumors susceptible to necrosis when an appropriate compound is administered followed by illumination with light of a wavelength absorbed by the compound, the compounds being dihydro porphyrins of the formula, or the corresponding tetra-hydro porphyrins: ##STR1## where n=1 to 3 and each substituent R, the same or different and at the same or different position in its respective substituent phenyl ring, is an hydroxy group.

REFERENCES:
patent: 4783529 (1988-11-01), Lavallee et al.
patent: 4992257 (1991-02-01), Bonnett et al.
Merck Index [Merck and Co., Rahway, N.J., 1989], p. 172.
Cooper, Spectroscopic Techniques for Organic Chemistry, [New York, J. Wiley and Sons, 1980], p. 243.
Crossley et al., JACS, 1987, 109, 341-348.
Whitlock, JACS, 91(26) 1989 7485-7489.

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