Porphyrin-metal complexes and oxygen infusions containing...

Details Porphyrin-metal complexes and oxygen infusions containing... Porphyrin-metal complexes and oxygen infusions containing...

2006-10-24

2006-10-24

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S009100, C514S021800, C514S410000, C534S015000, C540S145000

Reexamination Certificate

active

07125862

ABSTRACT:
A porphyrin metal complex that can form a stable oxygen complex and acts effectively as an oxygen infusion, which comprises:a transition metal ion M of period 4 or 5 coordinating to a porphyrin derivative represented by the following generalwherein R1is an alicyclic hydrocarbon group which may contain a substituent, R2is an alkylene group and R3is a group which does not hinder the coordination of an imidazolyl group to M.

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Teruyuki Komatsu et al, “Effect of Heme Structure on O2-Binding Properties of Human Serum Albumin— Heme Hybrids: Intramolecular Histidine Cooridantion Provides a Stable O2—Adduct Complex”, Bioconjugate Chem., vol. 13, pp. 397-402, 2002.
Teruyuki Komatsu et al., “O2-adduct complex of meso-tetrakis (α, α, α, α-o-pivalamidophenyl) porphinatoiron (II) with an intramolecularly coordinated proximal histidine,” Chemistry Letters, No. 7, pp. 668 to 669, 2001.

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