Porphyrin derivatives for photodynamic therapy

Details Porphyrin derivatives for photodynamic therapy Porphyrin derivatives for photodynamic therapy

2008-05-13

2008-05-13

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S121000, C540S145000, C514S410000, C424S009362, C424S009610, C534S015000

Reexamination Certificate

active

07371742

ABSTRACT:
This invention relates to porphyrin compounds used to destroy or impair the functioning of a target biological material in photodynamic therapy, in particular against virus, tumoral cells, bacteria, tumorous tissues. The invention also relates to compositions containing such compounds and to a method in vitro to photosensitize detroy or impair the functioning of such target biological material.

REFERENCES:
patent: 2709491 (1995-03-01), None
patent: 2709491 (1995-03-01), None
Ahmad et al. Involve,emt of retinoblastoma (Rb) and E2F transcription factors during photodynamic therapy of human epidermoid carcinoma cells A431. Oncogene (1999) 18, pp. 1891-1896.
Berg et al. CAS registry and reference. Mitotic inhibition by phenylporphines and tetrasulfonated aluminum phthalocyanine in combination with light. Photochemistry and Photobiology (1992), 56(3) pp. 333-339.
Guo et al . CAS registry and reference. Synthesis of glycoconjugated metalloporphyrins and their selective catalysis for alkaqne oxidation under mild conditions. Huaxue Xuebao (2000) 58(3) pp. 332-337.
Pasetto et al. Synthesis of hydrolytically stable porphyrin C- and S-glycoconjugates in high yields. Chemical Communications (2001) pp. 81-82.
Zhang et al. Synthesis of acetylglycosylated metalloporphyrins and their catalysis for cyclohexane oxidation with PhlO under mild conditions. J. of Molecular Catalysis (2000) 154 pp. 31-38.
“Synthesis of hydrolytically stable porphyrin C-and S-glycoconjugates in high yields”, P. Pasetto, et al. Chem. Commun. (Cambridge), 2001, 81-82.
“Phytodynamic therapy of experimental introcular retinoblastomas-dose-response relationships to light energy and Photofrin II”, J. Winther, et al., Acta Ophthalmologica 1989, pp. 44-50.

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