Porphyrin derivatives and their use in photodynamic therapy

Details Porphyrin derivatives and their use in photodynamic therapy Porphyrin derivatives and their use in photodynamic therapy

2007-07-17

2007-07-17

Wilson, James O. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C424S009362, C424S009610, C534S015000, C514S185000, C514S410000

Reexamination Certificate

active

10744863

ABSTRACT:
A compound of formula I:wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilizing solutions comprising a compound of the invention, and the use thereof, are also disclosed.

REFERENCES:
patent: 4318883 (1982-03-01), Polony et al.
patent: 4775625 (1988-10-01), Sieber
patent: 4878891 (1989-11-01), Judy et al.
patent: 4962197 (1990-10-01), Foley et al.
patent: 5179120 (1993-01-01), Vogel et al.
patent: 5212300 (1993-05-01), Ellis, Jr. et al.
patent: 5280115 (1994-01-01), Ellis, Jr. et al.
patent: 5345008 (1994-09-01), Lyons et al.
patent: 5409900 (1995-04-01), Vogel et al.
patent: 5489716 (1996-02-01), Ellis, Jr. et al.
patent: 5493017 (1996-02-01), Therien et al.
patent: 5545516 (1996-08-01), Wagner
patent: 5599924 (1997-02-01), Therien et al.
patent: 5637608 (1997-06-01), Vogel et al.
patent: 5663328 (1997-09-01), Ellis, Jr. et al.
patent: 5703230 (1997-12-01), Boyle et al.
patent: 5756723 (1998-05-01), Therien et al.
patent: 5847114 (1998-12-01), Thetford et al.
patent: 5864044 (1999-01-01), Van Lier et al.
patent: 6107326 (2000-08-01), Jori
patent: 6208553 (2001-03-01), Gryko et al.
patent: 6272038 (2001-08-01), Clausen et al.
patent: 6324091 (2001-11-01), Gryko et al.
patent: 6407330 (2002-06-01), Lindsey et al.
patent: 6420648 (2002-07-01), Lindsey
patent: 6433162 (2002-08-01), Nickel et al.
patent: 6573258 (2003-06-01), Bommer et al.
patent: 6596935 (2003-07-01), Lindsey et al.
patent: 6630128 (2003-10-01), Love et al.
patent: 6642376 (2003-11-01), Lindsey et al.
patent: 6812343 (2004-11-01), Osuka
patent: 6857926 (2005-02-01), Sulcs et al.
patent: 6951935 (2005-10-01), Zhang et al.
patent: 2002/0183245 (2002-12-01), Hasan et al.
patent: 2003/0176326 (2003-09-01), Nifantiev
patent: 2004/0014738 (2004-01-01), Dubbelman et al.
patent: 0 196 515 (1986-10-01), None
patent: 0 906 758 (1999-04-01), None
patent: 1 197 147 (2002-04-01), None
patent: 1 197 229 (2002-04-01), None
patent: WO 95/33463 (1995-12-01), None
patent: WO 96/05862 (1996-02-01), None
patent: WO 96/31452 (1996-10-01), None
patent: WO 98/31219 (1998-07-01), None
patent: WO 98/33503 (1998-08-01), None
patent: WO 98/39011 (1998-09-01), None
patent: WO 98/52610 (1998-11-01), None
patent: WO 99/66962 (1999-12-01), None
patent: WO 00/09111 (2000-02-01), None
patent: WO 00/12512 (2000-03-01), None
patent: WO 00/52012 (2000-09-01), None
patent: WO 00/74674 (2000-12-01), None
patent: WO 01/96343 (2001-12-01), None
patent: WO 02/10173 (2002-02-01), None
patent: WO 02/13820 (2002-02-01), None
patent: WO 02/30190 (2002-04-01), None
patent: WO 02/30475 (2002-04-01), None
patent: WO 03/008430 (2003-01-01), None
patent: WO 03/057176 (2003-07-01), None
patent: WO 03/086389 (2003-10-01), None
patent: WO 04/035590 (2004-04-01), None
patent: WO 2004/035590 (2004-04-01), None
patent: WO 04/046151 (2004-06-01), None
patent: WO 04/069273 (2004-08-01), None
patent: WO 05/058909 (2005-06-01), None
Hamblin et al. Rapid Control of Wound Infections by Targeted Photodynamic Therapy Monitored by In Vivo Bioluminescence Imaging. Nov. 28, 2001., Photochemistry and Photobiology, 2002 75(1) pp. 51-57.
Bellin, et al., “Effects of photodynamic action onE. coli”, Arch. Biochem. Biophys. 132: 157-164 (1969).
Bertoloni, et al., “Photosensitizing activity of water- and lipid-soluble phthalocyanines onEscherichia coli,” FEMS Microbiol. Lett. 59: 149-155 (1990).
Bertoloni, et al., “Photosensitizing activity of water- and lipid-soluble phthalocyanines on prokaryotic and eukaryotic microbial cells,”Microbios, 71: 33-46 (1992).
Borocci, et al.,Chemical Abstracts136: 69974 (2001) (abstract only).
Breuer, et al., “Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis,”Br. J. Dermatol.147: 55-61 (2002).
Brückner, et al., “Novel and improved synthesis of 5,15-diphenylporphyrin and its dipyrrolic precursos”,J. Porphyrins Phthalocyanines, 2: 455-465 (1998).
Ceburkov & Gollnick, “Photodynamic therapy in dermatology,”Eur. J. Dermatol.10(7): 568-75 (2000).
Diwu & Lown, “Phototherapeutic potential of alternative photosensitizers to porphyrins”,Pharmacol. Ther.63: 1-35 (1994).
Dougherty, “An update on photodynamic therapy applications,”J. Clin. Laser Med. Surg.20(1): 3-7 (2002).
Ehrenberg, et al., “Fluorescence spectral changes of hematoporphyrin derivative upon binding to lipid vesicles,Staphylococcus aureusandEscherichia colicells,”Photochem. and Photobiol. 41: 429-435 (1985).
Geyer, et al., “Subophthalocyanines: Preparation, reactivity and physical properties”,Synthesis1139-1151 (1996).
Hopper, “Photodynamic therapy: a clinical reality in the treatment of cancer,”Lancet Oncol. 1:212-219 (2000).
Jorgensen & Ferraro, “Antimicrobial susceptibility testing: special needs for fastidious organisms and difficult-to-detect resistance mechanisms,”Clin. Infect. Dis.30(5): 799-808 (2000).
Kassab, et al., “Phthalocyanine-photosensitized inactivation of a pathogenic protozoan,Acanthamkoeba palestinensis”, Photochem. Photobiol. Sci.2(6): 668-672 (2003).
Kudrevich, et al., “Syntheses of trisulfonated phthalocyanines and their derivatives using boron(III) subphthalocyanines as intermediates”,J. Org. Chem.61: 5706-5707 (1996).
Kuroyanagi, et al., “Extremely sensitive detection of photoresponses in ultrathin films containing porphyrins by the optical waveguide”,Chemical Abstracts124: 131104 (1995) (abstract only).
Li, et al., “A series of meso-tris(N-methyl-pyridiniumyl)-(4-alkylamidophenyl) porphyrins: Synthesis, interaction with DNA, and antibacterial activity”,Biochem. Biophys. Acta1354: 252-260 (1997).
Lin, et al., “Photosensitization, uptake, and retention of phenoxazine Nile blue derivatives in human bladder carcinoma cells,”Cancer Res.51: 1109-1116 (1991).
Liu, et al., “Synthesis of tail-type pyridinium(triethylammonium)-porphyrin quaternary ammonium salt”,Chemical Abstracts133: 104912 (2000) (abstract only).
Malik, et al., “Bactericidal effects of photoactivated porphyrins—an alternative approach to antimicrobial drugs,”J. Photochem. Photobiol. B5(3-4): 281-293 (1990).
Malik, et al., “Photodynamic inactivation of Gram-negative bacteria: problems and possible solutions,”J. Photochem. Photobiol. B14: 262-266 (1992).
Mehta, et al., “Cholate-interspersed porphyrin-anthraquinone conjugates: Photonuclease activity of large sized, ‘tweezer-like’ molecules”,J. Chem. Soc. Perkin. Trans 1, 2177—2181 (1999).
Merchat, et al., “Meso-substituted cationic porphyrins as efficient photosensitizers of gram-positive and gram-negative bacteria,”J. Photochem. Photobiol. B.32: 153-157 (1996).
Merchat, et al., “Studies on the mechanism of bacteria photosensitization by meso-substituted cationic porphyrins,”J. Photochem. Photobiol. B.35: 149-157 (1996).
Minnock, et al., “Photoinactivation of bacteria. Use of a cationic water-soluble zinc phthalocyanine to photoinactivate both gram-negative and gram-positive bacteria,”J. Photochem. Photobiol. B.159-164 (1996).
Moan, et al., “The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin,”Br J Cancer39: 398-407 (1979).
Monti, et al., “Micelle-bound metalloporphyrins as highly selective catalysts for the epoxidation of alkenes”,Chemical Abstracts129: 81626 (1998) (abstract only).
Mosmann, et al., “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,”J.

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