Porphycene compounds for photodynamic therapy

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540465, 540472, 536174, 536187, 424 11, 604 20, A61K 3140, C07D48722

Patent

active

051791200

ABSTRACT:
A porphycene having the structure ##STR1## wherein each R.sup.1 is, independently, (a) --(CH.sub.2).sub.n --X, where n=1-4, X is OR.sup.2 and R.sup.2 is C.sub.1-6 alkyl, aralkyl or aryl; CN; OH; OSO.sub.2 R.sup.2 ; NH.sub.2 ; NHR.sup.2 ; NR.sub.2.sup.2 ; SH; SR.sup.2 ; S(O).sub.1-2 R.sup.2 ; COOH; CO.sub.2 R.sup.2 ; C(O)NH.sub.2 ; C(O)NHR.sup.2 ; C(O)NR.sub.2.sup.2 ; halogen; or CHO;

REFERENCES:
patent: 3592930 (1971-07-01), Katz et al.
patent: 3989815 (1976-11-01), Rajadhyaksha
patent: 3989816 (1976-11-01), Rajadhyaksha
patent: 3991203 (1976-11-01), Rajadhyaksha
patent: 4017615 (1977-04-01), Shastri et al.
patent: 4411893 (1983-10-01), Johnson et al.
patent: 4448765 (1984-05-01), Ash et al.
patent: 4721612 (1988-01-01), Janoff et al.
patent: 4837028 (1989-06-01), Allen
patent: 4861876 (1989-08-01), Kessel
patent: 4913907 (1990-04-01), Jori et al.
patent: 4957481 (1990-09-01), Gatenby
patent: 4961920 (1990-10-01), Ward
patent: 4996312 (1991-02-01), Sakata et al.
Tetrahedron Letters No. 50, (1975), pp. 4467-4470, "A Convenient Synthesis of Acetylenes: Catalytic Substitutions of Acetylenic . . . " Sonogashira et al.
J. Org. Chem, (1976), vol. 41, pp. 2826-2835, "Pyrrole Chemistry. The Cyanovinyl Aldehyde Protecting Groups", Paine et al.
J. Org. Chem, (1988), vol 53, pp. 2787-2795, "5-Unsubstituted 2-pyrrolecarboxaldehydes For Porphyrin Synthesis and the Cyanovinyl . . . " Paine et al.
Angew. Chem. Int. Ed. Engl., (1988), vol 27, pp. 1170-1172, "Biomimentic Synthesis of an Octabinylogous Porphyrin with an Aromatic . . . " Knubel et al.
Angew. Chem. Int. Ed. Engl, (1986), 25, pp. 1100-1101, "Synthesis of a Fourfold Enlarged Porphyrin with an Extremely Large, Diamagnetic Ring . . . " Gosmann et al.
J. Org. Chem., (1987), 52, pp. 710-711, "Synthesis of a [1,5,1,5]Platyrin, a 26-Electron Tetrapyrrolic Annulene", Schlessinger et al.
J. Am. Chem. Soc, (1988), 110, pp. 5586-5588, "An `Expanded Porphyrin`: The Synthesis and Structure of a New Aromatic Pentadentate . . . ", Sessler et al.
Tetrahedron Letters No. 44, (1978), pp. 4225-4228, "The Synthesis of a 22-Electron Tetrapyrrolic Macrocycle, [1,3,1,3]Platyrin", Berger et al.
Chemistry Letters, (1973), pp. 1041-1044, "Reductive Coupling of Carbonyl Compounds to Pinacols and Olefins by Using . . . " Mukaiyama et al.
J. Am. Chem. Soc., (1974), 96, pp. 4708-4709, "A New Method for the Reductive Coupling of Carbonyls to Olefins, Synthesis of -Carotene", McMurry et al.
Organic Synthesis, pp. 880-883, "Palladium Catalyst for Partial Reduction of Acetylenes", Lindlar et al.
Cancer Research, (1978), 38, pp. 2628-2633, "Phtoradiation Therapy for the Treatment of Malignant Tumors", Dougherty et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Porphycene compounds for photodynamic therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Porphycene compounds for photodynamic therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Porphycene compounds for photodynamic therapy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1220525

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.