Porphycene compounds for photodynamic therapy

Details Porphycene compounds for photodynamic therapy Porphycene compounds for photodynamic therapy

1992-04-29

1993-11-16

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 174, 536 181, 540472, 424 9, 604 20, A61K 3170, C07H 1500

Patent

active

052624013

ABSTRACT:
A porphycene having the structure ##STR1## wherein each R.sup.1 is, independently, (a) --(CH.sub.2).sub.n --X, where n= 1-4, X is OR.sup.2 and R.sup.2 is C.sub.1-6 alkyl, aralkyl or aryl; CN; OH; OSO.sub.2 R.sup.2 ; NH.sub.2 ; NHR.sup.2 ; NR.sup.2.sub.2 ; SH; SR.sup.2 ; S(O).sub.1-2 R.sup.2 ; COOH; CO.sub.2 R.sup.2 ; C(O)NH.sub.2 ; C(O)NHR.sup.2 ; C(O)NR.sup.2.sub.2 ; halogen; or CHO;

REFERENCES:
patent: 5015478 (1991-05-01), Jori et al.
patent: 5124449 (1992-06-01), Franck et al.
patent: 5132101 (1992-07-01), Vogel et al.
Experimental Photodynamic Therapy with Tetrapropyl-Porphycene: Ultrastructural Studies on the Mechanism of Tumour Photodamage, Carla Milanesi, Roberta Biolo, Giulio Jori and Kurt Schaffner Lasers in medical science vol. 6, 437 1991. Dept. of Biology, University of Padova, Italy.

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