Porous structures, and methods of use

Details Porous structures, and methods of use Porous structures, and methods of use

2004-11-30

2010-06-15

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S423000, C424S413000, C424S426000, C424S400000

Reexamination Certificate

active

07736669

ABSTRACT:
The present invention provides porous structures that each comprise chitosan, alginate and divalent metal cations, wherein: (a) the chitosan is ionically linked to the alginate; and (b) the structure is porous and has a compressive yield strength of at least 0.35 MPa. The present invention also provides methods for making the porous structures, and methods for using the porous structures as substrates to grow living cells.

REFERENCES:
patent: 5830493 (1998-11-01), Yokota et al.
patent: 5836970 (1998-11-01), Pandit
patent: 5888987 (1999-03-01), Haynes et al.
patent: 6027744 (2000-02-01), Vacanti et al.
patent: 6150581 (2000-11-01), Jiang et al.
patent: 6171340 (2001-01-01), McDowell
patent: 6207218 (2001-03-01), Layrolle et al.
patent: 6699848 (2004-03-01), Barbeau
patent: 6836970 (2005-01-01), Hirano
patent: 2005/0118230 (2005-06-01), Hill et al.
Lai et al. The preparation and characterization of drug loaded alginate and chitosan sponges, Aug. 28, 2002, Internation Journal of Pharmaceutics.
Lai et al., The preparation and characterization of drug loaed alginate and chitosan sponges), of record.
Chu, T.M., et al., “Mechanical and in vivo performance of hydroxyapatite Implants With Controlled Architectures,”Biomaterials23:1283-1293, 2002.
Chung, T.W., et al., “Preparation of Alginate/Galactosylated Chitosan Scaffold for Hepatocyte Attachment,”Biomaterials23:2827-2834, Jul. 2002.
Coppi, G., et al., “Chitosan-Alginate Microparticles as a Protein Carrier,”Drug Dev. Ind. Pharm.27(5):393-400, 2001.
Dillon, G.P., “The Influence of Physical Structure and Charge on Neurite Extension in a 3D Hydrogel Scaffold,”J. Biomater. Sci. Polymer Edn9(10):1049-1069, 1998.
Dornish, M., et al., “Standards and Guidelines for Biopolymers in Tissue-Engineered Medical Products: ASTM Alginate and Chitosan Standard Guides,”Ann. New York Acad. Sci., 2001, pp. 388-397.
Gåserød, O., et al., “Microcapsules of Alginate-Chitosan. II. A Study of Capsule Stability and Permeability,”Biomaterials20:773-783, Apr. 1999.
Gutowska, A., et al., “Injectable Gels for Tissue Engineering,”Anat. Rec.263:342-349, 2001.
Hari, P.R., et al., “Chitosan/Calcium-Alginate Beads for Oral Delivery of Insulin,”J. Appl. Polymer Sci.59:1795-1801,1996.
Hutmacher, D.W., et al., “An Introduction to Biodegradable Materials for Tissue Engineering Applications,”Ann. Acad. Med. Singapore30(2):183-191, 2001.
Kim, H.J., “Polyelectrolyte Complex Composed of Chitosan and Sodium Alginate for Wound Dressing Application,”J. Biomater. Sci. Polymer Edn10(5):543-556, 1999.
Lauffenburger, D.A., and D.V. Schaffer, “The Matrix Delivers: Gene Therapy and Tissue Engineering Team Up to Speed Bone Regeneration,”Nat Med.5(7):733-734, 1999.
Li, J., et al., “Culture of Primary Rat Hepatocytes Within Porous Chitosan Scaffolds,”J. Biomed. Mat. Res.67A(3):938-943, Dec. 1, 2003.
Liu, L.-S., et al., “Controlled Release of Interleukin 2 for Tumor Immunotherapy Using Alginate/Chitosan Porous Microspheres,”J. Controlled Release43:65-74, Jan. 1997.
Muzzarelli, R.A., et al., “Stimulatory Effect on Bone Formation Exerted by a Modified Chitosan,”Biomaterials15:1075-1081, 1994.
Overgaard, S., et al., “Immobilization of Hybridoma Cells in Chitosan Alginate Beads,”Can. J. Chem. Eng.69(2):439-443, Apr. 1991.
Savant, V.D., and J.A. Torres, “Protein Adsorption on Chitosan-Polyanion Complexes: Application to Aqueous Food Processing Wastes,” in H. Chen and C. Weller (eds.),Structure and Functionality of Biopolymers, 2001, pp. 537-542.
Shanmugasundaram, N., et al., “Collagen-Chitosan Polymeric Scaffolds for the in vitro Culture of Human Epidermoid Carcinoma Cells,”Biomaterials22:1943-1951, 2001.
Sugimoto, M., et al., “Preparation and Characterization of Water-Soluble Chitin and Chitosan Derivatives,”Carbohydrate Polymers3649-59, 1998.
Suh, J.K., and H.W. Matthew, “Application of Chitosan-Based Polysaccharide Biomaterials in Cartilage Tissue Engineering: A Review,”Biomaerials21:2589-2598, 2000.
Takahashi, K.T., et al., “Characteristics of Polyion Complexes of Chitosan With Sodium Alginate and Sodium Polyacrylate,”Int. J. Pharm.61:35-41, 1990.
Thomson, R.C., et al., “Fabrication of Biodegradable Polymer Scaffolds to Engineer Trabecular Bone,”J. Biomater. Sci. Polym. Edn.7(1):23-38, 1995.
Wake, M.C., et al., “Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates,”Cell Transplant3(4):339-343, 1994.
Wang., L., et al., “Chitosan-Alginate-CaCl2System for Membrane Coat Application,”J. Pharm. Sci.90(8):1134-1142, Aug. 2001.
Whang, K., et al., “Engineering Bone Regeneration With Bioabsorbable Scaffolds With Novel Microarchitecture,”Tissue Eng.5(1):35-51, 1999.
Yang, S., et al., “The Design of Scaffolds for Use in Tissue Engineering. Part I. Traditional Factors,”Tissue Eng.7(6):679-689, 2001.
Zhang, Y., and M. Zhang, “Calcium Phosphate/Chitosan Composite Scaffolds for Controlled in vitro Antibiotic Drug Release,”J. Biomed. Mater. Res.62:378-386, 2002.
Zhang, Y., and M., Zhang, “Synthesis and Characterization of Macroporous Chitosan/Calcium Phosphate Composite Scaffolds for tissue Engineering,”J. Biomed. Mater. Res.55:304-312, 2001.
Zhang, Z., et al., “Pore Size, Tissue Ingrowth, and Endothelialization of Small-Diameter Microporous Polyurethane Vascular Prosthesis,”Biomaterials25:177-187, 2004.

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