Porous microspheres for drug delivery and methods for making sam

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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34 5, 264 46, 424486, 424492, 424497, 424499, 424501, 424DIG7, 4272133, 42721231, 42721335, 42721336, 42840224, 514965, A61K 916, A61K 950, A61K 952, B01J 1302

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048185426

ABSTRACT:
Controlled release drug delivery systems comprised of spherical microporous polymeric network of interconnecting channels containing pore incorporated drugs or other agents wherein the drugs or agents are confined within the pore channel are described. Also disclosed are processing parameters in connection with the novel method of the invention for obtaining drug delivery systems especially suited for parenteral as well as oral administration.

REFERENCES:
patent: 3460972 (1969-08-01), Nack
patent: 3737337 (1973-06-01), Schnoring et al.
patent: 3943063 (1976-03-01), Morishita et al.
patent: 4384975 (1983-05-01), Fong
Beck et al.: "A New Long-Acting Injectable Microcapsule System . . . ", Fertility and Sterility, vol. 31, No. 5, May 1979, pp. 545-551.
Fong et al.: "Evaluation of Biodegradable Microspheres Prepared by a Solvent Evaporation Process . . . ", J. of Controlled Release, 3 (1986) 119-130.

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