Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1985-11-18
1987-10-27
Kight, John
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, 424486, 424 78, 514953, 514964, 604890, 604891, 264 41, 521 64, 521182, 523113, A61K 900, A61L 2500
Patent
active
047029170
ABSTRACT:
Polylactones blended with a polyether and then shaped are leached with aqueous solution of an organic solvent such as alcohol or acetone to elute selectively the polyether and form interconnected pores within the shaped polylactone. The result is a shaped article suitable for use a reservoir for the controlled release of high molecular weight drugs.
REFERENCES:
patent: 3423491 (1969-01-01), McLain et al.
patent: 3887699 (1975-06-01), Yolles
patent: 4076656 (1978-02-01), White et al.
patent: 4148871 (1979-04-01), Pitt et al.
Gogolewski et al., "Biodegradable Materials of Polylactides, 4.sup.a) Porous Biomedical Materials Based on Mixtures of Polylactides and Polyurethanes", Makromol. Chem., Rapid Commun., 3, 839-845, (1982).
Gogolewski et al., "Growth of a Neo-Artery Induced by a Biodegradable Polymeric Vascular Prosthesis", Makromol. Chem., Rapid Commun., 4, 213-219, (1983).
Gegolewski et al., "Resorbable Materials of Poly(L-Lactide), III, Porous Materials for Medical Application", Colloid and Polymer Sci. 261, 477-484, (1983).
Kight John
Nutter Nathan M.
Research Triangle Institute
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