Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-07-25
2006-07-25
Salimi, Ali R. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S069100, C435S091200
Reexamination Certificate
active
07081342
ABSTRACT:
Substantially avirulent forms of atypical porcine reproductive and respiratory syndrome (PRRS) virus and corresponding vaccines are provided which result from cell culture passaging of virulent forms of PRRS. The resultant avirulent atypical PRRS virus is useful as a vaccine in that PRRS specific antibody response is elicited by inoculation of host animals, thereby conferring effective immunity against both previously known strains of PRRS virus and newly isolated atypical PRRS virus strains. The preferred passaging technique ensures that the virus remains in a logarithmic growth phase substantially throughout the process, which minimizes the time required to achieve attenuation. The present invention also provides diagnostic testing methods which can differentiate between animals infected with field strains and attenuated strains of PRRSV.
REFERENCES:
patent: 4554159 (1985-11-01), Roizman et al.
patent: 5476778 (1995-12-01), Chladek et al.
patent: 5510258 (1996-04-01), Sanderson et al.
patent: 5587164 (1996-12-01), Sanderson et al.
patent: 5698203 (1997-12-01), Visser et al.
patent: 5840563 (1998-11-01), Chladek et al.
patent: 5846805 (1998-12-01), Collins et al.
patent: 5925359 (1999-07-01), Woensel et al.
patent: 6042830 (2000-03-01), Chladek et al.
patent: 595436 (1994-05-01), None
patent: 0676467 (1995-04-01), None
patent: 9303760 (1993-03-01), None
patent: 9418311 (1994-08-01), None
patent: W) 97/31652 (1997-09-01), None
Andreyev, et al.; Genetic variation and phylogenetic relationships of 22 porcine reproductive and respiratory syndrome virus (PRRSV) field strains based on sequence analysis of open reading frame 5; Arch Virol (1997) 142: 993-1001.
Flint et al; Virus Cultivation, Detection, and Genetics; Arch Virol (2000) Chapter 2 40-42.
Gong et al.; Characterization of RNA Synthesis during a one-step growth curve and of the replication mechanism of bovine viral diarrhoea virus; Journal of General Virology (1996) 77 2729-2736.
Horsfall et al.; General Principles of Animal Virus Multiplication; Viral and Rickettsial Infections of Man (1965) 239-241.
Mengeling et al.; An update of research at the National Animal Disease Center on current field strains of Porcine Reproductive and Respiratory Syndrome (PRRS) virus; 1997 Allen D. Leman Swine Conference; 138-145.
Nuttall; Growth Characteristics of Two Strains of Bovine Virus Diarrhoea Virus; Arch Virol (1980) 66 365-369.
Wesley et al.; Differentiation of Vaccine (Strain RespPRRS®) and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus by Restriction Enzyme Analysis; American Association of Swine Practitioners (1996) 141-143.
For purification of viral RNA from Plasma, Serum, Cell-free body fluids, Cell-culture supernatants; QIAamp® Viral RNA Mini Kit Handbook; QIAGEN (1999) Cat # 52906 1-35.
Enzo Biochem Inc. v Gen-Probe Incorporated et al; No. 01-01230; Decided Jul. 15, 2002.
Burkhart Kelly
Gorcyca David E.
Lager Kelly
Mengeling William L.
Roof Mike
Boehringer Ingelheim Vetmedica, Inc.
Hovey & Williams, LLP
Salimi Ali R.
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