Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2004-12-23
2009-12-15
Mosher, Mary E (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
Reexamination Certificate
active
07632636
ABSTRACT:
A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.
REFERENCES:
patent: 2002/0172690 (2002-11-01), Calvert et al.
Labarque et al., “Effect of cellular changes and onset of humoral immunity on the replication of porcine reproductive and respiratory syndrome virus in the lungs of pigs,” Journal of General Virology, 81:1327-1334 (2000).
Halbur et al., “Effects of different US isolates of porcine and reproductive and respiratory syndrome virus on blood and bone marrow parameters of experimentally infected pigs,” The Veterinary Record, p. 344-347 (2002).
Shin et al., “Assessment of Porcine Reproductive and Respiratory Syndrome Virus RNA Load in Sera and Tissues during Acute Infection,” J. Vet. Sci., 3(2), pp. 75-85 (2002).
van der Linden et al (Vaccine 21:1952-1957, 2003).
Quantitative relationship of systemic virus concentration on growth and immune response in pigs; L.L. Greiner, T.S. Stahly, and T.J. Stabel; Department of Animal Science Iowa State Univ Ames IA and National Animal Disease Center, Ames, IA; pp. 2690-2695, Journal of Animal Science 78:2690-2695, 2000.
A Simple Method of Estimating Fifty Per Cent Endpoints, The American Journal of Hygiene; L.J. Reed and H. Muench; vol. 27, May, 1938, No. 3; pp. 493-497.
Adjuvant Danger Signals Increase the Immune Response to Porcine Reproductive and Respiratory Syndrome Virus; Dennis L. Foss, Michael J. Zillox, William Meier, Federico Zuckermann, and Michael P. Murtaugh; Viral Immunology, vol. 15, No. 4, 2002 pp. 557-566.
Clinical effects of porcine reproductive and respiratory syndrome virus on pigs during the early postnatal invterval; William L. Mengeling, Kelly M. Lager, Ann C. Vorwald; AJVR, vol. 59, No. 1, Jan. 1988; pp. 52-55.
Clinical Manifestations of PRRS Virus: B. Thacker; 2003 PRRS Compendium, 2nd Edition; pp. 7-15.
Clinical signs and economic losses caused by porcine reproductive and respiratory syndrome virus in a large breeding farm; Zygmunt Pejsak, Tomasz Stadejek, Iwona Markowska-Daniel; Veterinary Microbiology.55,(1997) pp. 317-322.
Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model; Patrick G. Halbur, Prem S. Paul, Xiang-Jin Meng, Melissa A. Lum, John J. Andrews, John A. Rathje; College of Veterinary Medicine, Iowa Statue Univ.; Ames, IA; pp. 11-20, J. Vet. Diagn. Invest. 8:11-20, 1996.
Comparative safety and efficacy of attenuated single-strain and multi-strain vaccines for porcine reproductive and respiratory syndrome; William L. Mengeling, Kelly M. Lager, Ann C. Vorwald, Deborah F. Clouser, Veterinary Microbiology 93 (2003) pp. 25-38.
Comparison of Molecular and Biological Characteristics of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Vaccine (Ingelvac PRRS MLV), the Parent Strain of the Vaccine (ATCC VR2332), ATCC VR 2385, and Two Recent Field Isolates of PRRSV; T. Opriessnig, P.G. Halbur, K-J Yoon, R.M. Pogranichniy, K.M. Harmon, R. Evans, K.F. Key, F.J. Pallares, P. Thomas and X.J. Meng; Journal of Virology, Dec. 2002, pp. 11837- 11844.
Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains; Shishan Yuan, Daniel Mickelson, Michael P. Murtaugh, Kay S. Faaberg; Virus Research 74 (2001) pp. 99-110.
Effects of different US isolates of porcine reproductive and respiratory syndrome virus (PRRSV) on blood and bone marrow parameters of experimentally infected pigs; P.G. Halbur, F.J. Pallares, J.A. Rathje, R. Evans, W.A. Hagemosser, P.S. Paul, X.J. Meng: The Veterinary Record, Sep. 21, 2002, pp. 344-348.
Effects of Low (Modified-live Virus Vaccine) and High (VR-2385)-Virulence Strains of Porcine Reproductive and Respiratory Syndrome Virus on Pulmonary Clearance of Copper Particles in Pigs; R. Thanawongnuwech, P.G. Halbur, M.R. Ackermann, E.L. Thacker, and R.L. Royer; Veterinary Pathology, Iowa State University, Ames, IA (1998) ; pp. 398-406, Vet. Pathol. 35:398-406, 1998.
Efficacy of modified live virus porcine reproductive and respiratory virus vaccines against heterologous respiratory challenge; M.B. Roof, E.M. Vaughn, K.M. Burkhart, K.S. Faaberg; Boehringer Ingelheim Vetmedica Inc. Research and Development, Ames, IA, USA, Dept of Veterinary Pathobiology, University of Minnesota, St. Paul, MN; 4th International Symposium on Emerging and Re-emerging Pig Diseases-Rome, Jun. 29-Jul. 2, 2003, pp. 117-118.
Evolution of Porcine Reproductive and Respiratory Syndrome Virus during Sequential Passages in Pigs; C.C. Chang, K.J. Yoon, J.J. Zimmerman, K.M. Harmon, P.M. Dixon, C.M.T. Dvorak and M.P. Murtaugh; Journal of Virology, May 2002, pp. 4750-4763.
Genetic variation and phylogenetic analyses of the ORF5 gene of acute porcine reproductive and respiratory syndrome virus isolates: Kijona F. Key, Gholamreza Hasqshenas, Denis K. Guenette, Sabrina L. Swenson, Thomas E. Toth, Xiang-Jin Meng; Veterinary Microbiology 83 (2001) pp. 249-263.
Genetic variation and phylogenetic relationships of 22 porcine reproductive and respiratory syndrome virus (PRRSV) field strains based on sequence analysis of open reading frame 5; V.G. Andreyev, R.D. Wesley, W.L. Mengeling, A.C. Vorwald and K.M. Lager; Archives of Virology (1997) 142; pp. 993-1001.
Genetic variation in porcine reproductive and respiratory syndrome virus isolates in the midwestern United States; V. Kapur, M.R. Elam, T.M. Pawlovich and M.P. Murtaugh; Journal of General Virology (1996) 77, pp. 1271-1276.
Genetic variation in the PRRS Virus; M.P. Murtaugh, K.S. Faaberg, J. Laber, M. Elam and V. Kapur; Dept. of Veterinary PathoBiology, University of Minnesota, St. Paul, MN; pp. 787-794, 1998.
Genomic characterization of virulent, attenuated, and revertant passages of a North American porcine reproductive and respiratory syndrome virus strain; T.V. Grebennikova, D.F. Clouser, A.C. Vorwald, M.I. Musienko, W.L. Mengeling, K.M. Lager, R.D. Wesley, S.F. Biketov, A.D. Zaberezhny, T.I. Aliper and E.A. Nepokionov; Virology 321 (2004) pp. 383-390.
Heterogeneity of porcine reproductive and respiratory syndrome virus; implications for current vaccine efficacy and future vaccine development; X.J. Meng; Veterinary Microbiology 74 (2000) pp. 309-329.
Identification of Neutalizing and Nonneutralizing Epitopes in the Porcine Reproductive and Respiratory Syndrome Virus GP5 Ectodomain; M. Ostrowskl, J.A. Galeota, A.M. Jar, K.P. Platt, F.A. Osorio, and O.J. Lopez; Journal of Virology, May 2002, pp. 4241-4260.
Immune responses in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV); E. Albina, L. Piriou, E. Hutet, R. Cariolet, R.L. Hospitalier, Veterminary Immunology and Immunopathology 61 (1998) pp. 49-66.
Immunological Responses of Swine to Porcine Reproductive and Respiratory Syndrome Virus Infection; Michael P. Murtaugh, Zhengguo Xiao, and Federico Zuckerrnann; Viral Immunology, vol. 15, No. 4, 2002; pp. 533-547.
Is Human Immunodeficiency Virus RNA Load Composed of Neutralized Immune Complexes?: Ferdinando Diazani, Guido Antonelli, Elisabetta Riva, Ombretta Turriziani, Laura Antonelli, Stephen Tyring, Daniel A. Carrasco, Hung Lee, Derrick Nguyen, Jingzhi Pan, Joyce Poast, Miles Cloyd, and Samuel Baron; Journal of Infectious Diseases 2002:185; pp. 1051-1054.
Role of Viral Porteases in PRRS Immunity; Final Report: Aug. 30, 2003; Michael P. Murtaugh; Dept. of Veterinary PathoBiology, University of Minnesota, St. Paul, MN and Boehringer Ingelheim Vetmedica Inc, Ames IA: pp. 1-38, 2003.
Nidovirales: a new order comprising Coronaviridae and Arterviridae; D. Cavanagh; Virology Divison News; Arch Virol 14
Johnson Wesley
Roof Michael
Vaughn Eric
Boehringer Ingelheim Vetmedica, Inc.
Devlin Mary-Ellen M.
Morris Michael P.
Morrison Joyce L.
Mosher Mary E
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