Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1983-08-29
1986-09-09
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, C07K 710, A61K 3724
Patent
active
046109765
ABSTRACT:
The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu -Gln-Gly-Ala-Arg-Val-Arg-Leu-Y wherein Y is OH or NH.sub.2. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and, or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically. The peptides are useful in stimulating the release of GH and accelerating growth in warm-blooded non-human animals, particularly pigs, and in improving aquiculture.
REFERENCES:
Spiess et al., Biochemistry, 21, 6037-6040 (1982).
Spiess et al., Nature, 303, 532-535 (1983).
Esch et al., Biochemical and Biophysical Research Communications, 109, No. 1, 152-158 (1982).
Esch et al., The Journal of Biological Chemistry, 258, No. 3, 1806-1810 (1983), Feb. 10 issue.
Guillemin et al., Science, 218, 585-587 (1982).
8th American Peptide Symposium, Tucson, Ariz., 237 (1983), 5/22.
Schally et al., Endocrinology, 84(6), 1493-1506, 1969.
Bohlen Peter
Brazeau, Jr. Paul E.
Esch Frederick S.
Guillemin Roger C. L.
Ling Nicholas C.
Moezie F. T.
Phillips Delbert R.
The Salk Institute for Biological Studies
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