Porcine GRF

Details Porcine GRF Porcine GRF

1983-08-29

1986-09-09

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, C07K 710, A61K 3724

Patent

active

046109765

ABSTRACT:
The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu -Gln-Gly-Ala-Arg-Val-Arg-Leu-Y wherein Y is OH or NH.sub.2. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and, or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically. The peptides are useful in stimulating the release of GH and accelerating growth in warm-blooded non-human animals, particularly pigs, and in improving aquiculture.

REFERENCES:
Spiess et al., Biochemistry, 21, 6037-6040 (1982).
Spiess et al., Nature, 303, 532-535 (1983).
Esch et al., Biochemical and Biophysical Research Communications, 109, No. 1, 152-158 (1982).
Esch et al., The Journal of Biological Chemistry, 258, No. 3, 1806-1810 (1983), Feb. 10 issue.
Guillemin et al., Science, 218, 585-587 (1982).
8th American Peptide Symposium, Tucson, Ariz., 237 (1983), 5/22.
Schally et al., Endocrinology, 84(6), 1493-1506, 1969.

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