Porcine cytokines

Details Porcine cytokines Porcine cytokines

1995-05-26

1999-01-26

Ulm, John

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, 514 8, 514 12, 514885, 530351, 435 695, 435 6952, 435375, C07K 1452, A61K 3819

Patent

active

058635289

ABSTRACT:
A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.

REFERENCES:
patent: 5106733 (1992-04-01), Baker et al.
Yang et al., Xenotransplantation, 3:92-101 (1996).
Sablinski et al., Abstract Presented at Third Intl. Congress on Xenotransplantation, Boston (1995).
Breuer et al., Gene, 81:307-314 (1989).
Smith et al., J. Clinical Apheresis, 7:49-57 (1992).
Kashiwakura et al. (1991) Chem. Pharm. Bull vol. 39 (6), pp. 1495-1498.
Zhou et al. (1994) Biochim. Biophys. Acta vol. 1223, pp. 148-150.
Shull et al. (1992) Exp. Hematol. vol. 20 pp. 1118-1124.
Martin et al. (1990) Cell vol. 63, pp. 203-211.
Flanagan et al. (1991) Cell. vol. 64, pp. 1025-1035.

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