Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1995-05-26
1999-01-26
Ulm, John
Drug, bio-affecting and body treating compositions
Lymphokine
514 2, 514 8, 514 12, 514885, 530351, 435 695, 435 6952, 435375, C07K 1452, A61K 3819
Patent
active
058635289
ABSTRACT:
A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.
REFERENCES:
patent: 5106733 (1992-04-01), Baker et al.
Yang et al., Xenotransplantation, 3:92-101 (1996).
Sablinski et al., Abstract Presented at Third Intl. Congress on Xenotransplantation, Boston (1995).
Breuer et al., Gene, 81:307-314 (1989).
Smith et al., J. Clinical Apheresis, 7:49-57 (1992).
Kashiwakura et al. (1991) Chem. Pharm. Bull vol. 39 (6), pp. 1495-1498.
Zhou et al. (1994) Biochim. Biophys. Acta vol. 1223, pp. 148-150.
Shull et al. (1992) Exp. Hematol. vol. 20 pp. 1118-1124.
Martin et al. (1990) Cell vol. 63, pp. 203-211.
Flanagan et al. (1991) Cell. vol. 64, pp. 1025-1035.
Hawley Robert J.
Monroy Rodney L.
Pomath Paul D.
Rosa Margaret D.
Schacter Bernice Z.
BioTransplant, Inc.
Herron Charles J.
Mertz Prema
Olstein Elliot M.
Ulm John
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