Populations of cells that express flk-2 receptors

Details Populations of cells that express flk-2 receptors Populations of cells that express flk-2 receptors

2005-01-05

2008-12-16

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Hemic or immune system

C424S093700, C424S143100, C424S144100, C424S152100, C424S153100, C424S173100, C435S002000, C530S388200, C530S388220, C530S388700

Reexamination Certificate

active

07465464

ABSTRACT:
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG.1a(murine flk-2), FIG.1b(human flk-2) and FIG.2(murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG.1a, FIG.1band FIG.2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.

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