Populations of cells that express FLK-1 receptors

Details Populations of cells that express FLK-1 receptors Populations of cells that express FLK-1 receptors

2003-08-11

2008-11-04

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Hemic or immune system

C424S093700, C424S143100, C424S144100, C424S152100, C424S153100, C424S173100, C435S002000, C530S388200, C530S388220, C530S388700

Reexamination Certificate

active

07445798

ABSTRACT:
Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG.1a(murine flk-2), FIG.1b(human flk-2) and FIG.2(murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG.1a, FIG.1band FIG.2;ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.

REFERENCES:
patent: 4714680 (1987-12-01), Civin
patent: 4965204 (1990-10-01), Civin
patent: 5061620 (1991-10-01), Tsukamoto et al.
patent: 5130144 (1992-07-01), Civin
patent: 5185438 (1993-02-01), Lemischka
patent: 5270458 (1993-12-01), Lemischka
patent: 5283354 (1994-02-01), Lemischka
patent: 5367057 (1994-11-01), Lemischka
patent: 5621090 (1997-04-01), Lemischka et al.
patent: 5912133 (1999-06-01), Lemischka
patent: 0 317156 (1989-05-01), None
patent: 0 330191 (1989-08-01), None
patent: 0 395355 (1990-10-01), None
patent: WO 92/14748 (1992-09-01), None
Abcouwer et al., Biotechnology 7 (1989), pp. 939-946.
Andrews et al., Journal of experimental Medicine 169, 1721-1731 (1989).
Batuman et al., Journal of Immunology 130 (1983), pp. 1051-1055.
Bolen et al., FASEB 6 (1992), pp. 3403-3409.
Civin, Exp. Hematol. 15 (1987), pp. 10-17.
Copeland et al., Cell 63, 175-183 (1990).
Dexter & Spooncer, Annual Review of Cell Biology 3, (1987), pp. 423-441.
Flanagan and Leder, Cell 63, 185-194 (1990).
Hammerschmidt et al., Nature 340 (1989), pp. 393-397.
Hanks et al., Science 241, 42-52 (1988).
Hopp et al., Proc. Natl. Acad Sci. USA 78, (1981), pp. 3824-3828.
Ikuta et al., Cell 62 (1990), pp. 863-864.
Jones et al., Proc. Nat'l Acad. Sci. USA 85 (1988), pp. 3377-3381.
Jordan et al, Cell 61:953-963, Jun. 15, 1990.
Kabrun et al., Development 124 (1997), pp. 2039-2048.
Kim K. J. et al., “The Vascular Endothelial Growth Factor Proteins: Identification of Biologically Relevant Regions by Neutralizing Monoclonal Antibodies” Growth factors, vol. 7, pp. 53-64, 1994.
Lederman et al., Mol. Immunol. 11:1171-1181, 1991.
Lemischka et al., Cell 45, 917-927 (1986).
Li et al. PNAS 77:3211-3214, 1980.
Loken et al., Blood 69 (Jan. 1987), pp. 255-263.
Martin et al., Cell 63, 203-211.
Matthews et al., Cell 65:1143-1152, Jun. 28, 1991.
Matthews et al., PNAS 88:9026-9030, Oct. 1991.
Millauer et al., Cell 72:835-846, 1993.
Nakamura, et al., “Ex Vivo Generation of CD34+ cells from CD34− Hematopoietic cells” Blood, Dec. 15, 1999, vol. 94, No. 12, pp. 4053-4059.
Ngo et al., “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox” edited by Merz and Lee Grand, Blizkitauser, 433, 492-495, 1994.
Nocka, K. et al., “Expression of C-Kit gene products in known cellular targets of W mutations in normal and W mutant mice-evidence for an impaired C-Kit Kinase in mutant mice, Genes and Development” vol. 3, No. 6, pp. 739-920, 1989.
Nocka et al., “Candidate ligand for the C-kit transmembrane Kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors” vol. 9, No. 10, pp. 3287-3294, 1990.
Orr, Genetic Engineering News, p. 8 (Feb. 1991).
Peichev, et al., “Expression of VEGFR-3 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors” Blood, Feb. 1, 2000, vol. 95, No. 3, 953-958.
Rosnet et al., Oncogene 6:1641-1650, Sep. 1991.
Rosnet et al., Genomics 9:380-385, Feb. 1991.
Sarzani et al., Biochem Biophys Res Comm. 186(2) 706-714 Jul. 31, 1992.
Skolnick et al., Biotech 18:34-38, 2000.
Spangrude et al., Science 241, 58-62 (1988).
Streeten et al., Proc. Nat'l. Acad. Sci. 86 (1989), pp. 916-920.
Suda et al., Int'l Journal of Hematology 71 (2000), pp. 99-107.
Szilvassy et al., Blood 74 (1989), pp. 930-939.
Terman et al., Biochem Biophys Res Comm. 187(3) 1579, 1992.
Terman et al., Oncogene 6, 1676-1683 (1991).
Wek et al., Proc. Nat'l Acad. Sci, USA 86, (1989), pp. 4579-4583.
Wilks Proc, Natl, Acad. Sci. USA 86, 1603-1607 (1989).
Williams et al., Cell 63, 163-174 (1990).
Yamaguchi, et al., “flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors” Development 118, 489-498, 1993.
Yang et al., J. Neuroscience 16:6089-6099, 1996.
Zipori, Int'l, Journal of Cell Cloning 7 (1989), pp. 281-291.
Zsebo et al., “Stem Cell factor is encoded at the SI locus of the mouse and is the ligand for the C-Kit tyrosine Kinase receptor” Cell 63 (1990), pp. 213-224.
Zsebo et al., Cell 63 (1990), pp. 195-201.

Affiliated with

Also associated with

Rating

Populations of cells that express FLK-1 receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Populations of cells that express FLK-1 receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Populations of cells that express FLK-1 receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4049636