Poorly soluble medicaments supported on polymer substances in a

Details Poorly soluble medicaments supported on polymer substances in a Poorly soluble medicaments supported on polymer substances in a

1993-03-09

1996-10-29

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 7802, 424449, 424457, 424468, 424499, 427335, 427336, A61K 950, A61K 922, A61K 970, B05D 304

Patent

active

055694691

ABSTRACT:
A poorly soluble medicament is incorporated into particles of a crosslinked polymer which is swellable in water but insoluble in water, and the product obtained is brought into contact with a solvent able to swell the polymer. The product obtained by this treatment, and after being dried under vacuum, has a medicament dissolving rate which is considerably higher than that of the pure medicament.

REFERENCES:
patent: 282209 (1981-08-01), Tucker
patent: 303642 (1981-12-01), Kangas
patent: 312855 (1982-01-01), Grand
patent: 818517 (1989-04-01), Kwee et al.
patent: 4837031 (1989-06-01), Denton
patent: 4882167 (1989-11-01), Jang
patent: 5354560 (1994-10-01), Lovrecich
patent: 5449521 (1995-09-01), Lovrecich

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