Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2005-07-12
2005-07-12
Prouty, Rebecca E. (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S195000
Reexamination Certificate
active
06916472
ABSTRACT:
The present invention relates to paraoxonase genes, in particular PON3. The present invention provides isolated nucleotide sequence encoding PON3, wild type and mutant PON3 peptides. The present invention also provides methods for using PON3 to screen compounds for the ability to alter PON3 associated activities, methods for generating antibodies useful in the detection of PON3, and methods of treating and preventing oxidative damage, sepsis, chemical toxicity, and other conditions.
REFERENCES:
patent: 4657760 (1987-04-01), Kung et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4946778 (1990-08-01), Ladner et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5198346 (1993-03-01), Ladner et al.
patent: 5206344 (1993-04-01), Katre et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5225212 (1993-07-01), Martin et al.
patent: 5629193 (1997-05-01), Hudson et al.
patent: 5792639 (1998-08-01), Hudson et al.
patent: WO 84/03564 (1984-09-01), None
patent: WO 88/06630 (1988-09-01), None
patent: WO 90/02909 (1990-03-01), None
patent: WO 92/09690 (1992-06-01), None
patent: WO 93/03367 (1993-02-01), None
patent: WO 00/30425 (2002-05-01), None
Waterson R. Homo sapiens paroxonase 2 mRNA, GeneBank accession number AC 005021, submitted Dec. 21, 1999.
Machiedo et al., Surg. Gyn. & Obstet., 152:757-759 [1981].
Morris et al., Am. J. Vet. Res., 47:2554-2565 [1986].
Hoffman et al., J. Vet. Int. Med., 6:89-95 [1992].
Wolff, New Eng. J. Med., 324:486-488 [1991].
Ohlsson et al., Nature, 348:550-552 [1990].
K.A. Schulman et al., JAMA, 266:3466-3471 [1991].
Anderson and Young, Quantitative Filter Hybridization,in Nucleic Acid Hybridization[1985].
Wahl, et al., Meth. Enzymol., 152:399-407 [1987].
Gobinda et al., PCR Methods Applic., 2:318-22 [1993].
Ozols, Biochem J., 338:265 [1999].
Mochizuki et al., Gene, 213:149[1998].
Wilson et al., Nature, 368:32 [1994].
Clendenning et al., Genomics, 35:586 [1996].
Primo-Parmo et al., Genomics, 33:498 [1996].
Sorenson et al., PNAS, 92:7187 [1995].
Shih et al., J. Clin. Invest., 97:1630 [1996].
Furlong et al., Chem. Biol. Interact., 87:35 [1993].
La Du et al., Chem. Biol. Interact., 87:25 [1993].
Adkins et al., Am. J. Hum. Gent., 52:598 [1993].
Hassett et al., Biochemistry, 30:10141 [1991].
Triglia et al., Nucleic Acids Res., 16:8186 [1988].
Lagerstrom et al., PCR Methods Applic., 1:111-19 [1991].
Parker et al., Nucleic Acids Res., 19:3055-60 [1991].
Murray et al., Nucl. Acids Res., 17 [1989].
Graham and van der Eb, Virol., 52:456 [1973].
Kacian et al., Proc. Natl. Acad. Sci. USA, 69:3038 [1972].
Gluzman, Cell 23:175 [1981].
Chamberlin et al., Nature, 228:227 [1970].
Wu and Wallace, Genomics, 4:560 [1989].
H.A. Erlich (ed.),PCR Technology,Stockton Press [1989].
Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, NY, pp. 9.31-9.58 [1989].
Davis et al., Basic Methods in Molecular Biology, [1986].
Wilson et al., Cell, 37:767 [1984].
Ben-Bassat et al., J. Bacteriol., 169:751-757 [1987].
Miller et al., Proc. Natl. Acad. Sci. USA, 84:2718-1722 [1990].
Hochuli et al., J. Chromatogr., 411:177 [1987].
Janknecht et al., Proc. Natl. Acad. Sci. USA, 88:8972.
Stryer (ed.),Biochemistry,2nd ed, WH Freeman and Co. [1981].
Narang, Tetrahedron Lett., 39:3 9 [1983].
Itakura et al., Recombinant DNA,in Walton(ed.),Proceedings of the 3rd Cleveland Symposium on Macromolecules,Elsevier, Amsterdam, pp. 273-289 [1981].
Itakura et al., Annu. Rev. Biochem., 53:323 [1984].
Itakura et al., Science 198:1056 [1984].
Ike et al., Nucl. Acid Res., 11:477 [1983].
Cwirla et al., Proc. Natl. Acad. Sci. USA, 87:6378-6382 [1990].
Fuchs et al., BioTechnol., 9:1370-1371 [1991].
Goward et al., TIBS 18:136-140 [1992].
Marks et al., J. Biol. Chem., 267:16007-16010 [1992].
Griffths et al., EMBO J., 12:725-734 [1993].
Clackson et al., Nature, 352:624-628 [1991].
Barbas et al., Proc. Natl. Acad. Sci., 89:4457-4461 [1992].
Ruf et al., Biochem., 33:1565-1572 [1994].
Wang et al., J. Biol. Chem., 269:3095-3099 [1994].
Balint et al. Gene 137:109-118 [1993].
Grodberg et al., Eur. J. Biochem., 218:597-601 [1993].
Nagashima et al., J. Biol. Chem., 268:2888-2892 [1993].
Lowman et al., Biochem., 30:10832-10838 [1991].
Cunningham et al., Science, 244:1081-1085 [1989].
Gustin et al., Virol., 193:653-660 [1993].
Brown et al., Mol. Cell. Biol., 12:2644-2652 [1992].
Meyers et al., Science, 232:613 [1986].
Caruthers et al., Nucl. Acids Res. Symp. Ser., 7:215-233 [1980].
Crea and Horn, Nucl. Acids Res., 9:2331 [1980].
Matteucci and Caruthers, Tetrahedron Lett., 21:719 [1980].
Chow and Kempe, Nucl. Acids Res., 9:2807-2817 [1981].
Creighton,Proteins Structures And Molecular Principles,W H Freeman and Co, New York N.Y. [1983].
Roberge et al., Science, 269:202-204 [1995].
Tjoelker et al., Nature, 374:549-553 [1995].
Granjeaudhae et al., Immunogenetics, 49:964-972 [1999].
Esterbauer et al., Free Radical Res Commun, 6:67-75 [1989].
El-Saadani et al., J Lipid Res, 30:627-630 [1989].
Smith et al., Gene 67:31 [1988].
Köhler and Milstein, Nature, 256:495-497 [1975].
Kozbor et al., Immunol. Tod., 4:72 [1983].
Johnson et al., Am. J. Patholo., 88, 559-574, [1977].
Aviram et al., Arterioscler. Thromb. Vasc. Biol. 18:1617-1624 [1998].
Aviram, Mol. Med. Today 5:381-138 [1999].
Watson et al., J. Clin. Invest 96:2882-2891 [1995].
Shih et al., Nature, 394:284-287 [1998].
Langman and Cole, Clin. Chim Acta, 286:63-80 [1999].
Jakubowski, J. Biol. Chem., 275:3957-2962 [2000].
Billecke, et al., Chem Biol Interact, 119-120:251-256, [1999].
Sorenson et al., Thromb. Vasc. Biol., 19:2214-2225 [1999].
Laemmli, Nature, 227:680-685, [1970].
Kuo and La Du, Drug Metab. Dispos., 23:935 [1995].
Gan et al., Drug Metab Dispos, 19:100-106 [1991].
Augustinsson and Axenfors, Anal. Biochem., 48:428 [1972].
Haley et al. Toxicol. Applied Pharmacol., 157:227-233, [1999].
Cote et al., Proc. Natl. Acad. Sci. USA, 80:2026-2030 [1983].
Kieft et al., J Lipid Res, 32:859-866 [1991].
Hatch, Adv. Lipid Res., 6:1 [1968].
Aurrand-Lioons et al., Immunity, 5:391-405 [1996].
Costa et al., “The role of paraoxonase (PONI) in the detoxication of organophosphates and its human polymorphism,” Chem.-Biol. Interactions 119-120:429 [1999].
Zech et al., “Paraoxonase polymorphism in rabbits,” Chemico-Biol. Interactions 119-120:283 [1999].
Hegele “Paraoxonase genes and diseases,” Ann Med., 31:217 [1999].
Hegele et al. “Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree,” Clin. Genet. 54:394 [1998].
Rodrigo et al., “Purification and characterization of paroxon hydrolase from rat liver,” Biochem J., 321:595 [1997].
Boright et al., “Genetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites,” Atherosclerosis 139:131 [1998].
La Du “Human serum paroxonase/arylesterase” Pharmacogenetics of Drug Metabolism, Pergamon Press, New York, pp. 51-91.
Li et al., “Paroxonase (Pon1) gene in mice: sequencing, chromosomal localization and developmental expression,” Pharmacogenetics 7:137 [1997].
Sorenson et al., “Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase,” PNAS, 92:7187 [1995].
Humbert et al., “The molecular basis of the human serum paraoxonase activity polymorphism,” Nature Genetics 3:73 [1993].
Sorenson et al., “The genetic mapping and gene structure of mouse paraoxonase/arylesterase,” Genomics 30:431 [1995].
Sorenson et al., “Properties of the retained N-terminal hydrophobic leader sequence in human serum paraoxonase/arylesterase,” Chem Biol. Int. 119-120:599 [1999].
Josse et al., “Human serum paraoxonase (PONI): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis,” Chemico-Biologic. Interactions 119-120:71 [1999].
Josse et al., “Tryptophan residue(s) as majo
Draganov Dragomir I.
La Du Bert N.
Stetson Phillip L.
Watson Catherine E.
Medlen & Carroll LLP
Regents of the University of Michigan
Walicka Malgorzata A.
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