Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1989-01-17
1993-08-17
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
4351885, 435219, 43524027, 5303881, C12P 2106, C12N 905, C07K 1528
Patent
active
052368254
ABSTRACT:
A catalytic molecule comprising a receptor molecule containing an antibody combining site that immunologically binds to a plurality of polyvalent metal ion-containing coordination complexes is disclosed. The coordination complex of a first immunoligand is kinetically inert, whereas the coordination complex of a second immunoligand is kinetically labile. The receptor molecule catalyzes a reaction of the second immunoligand. Immunogens, antigens, and methods of making and using the catalytic receptors are disclosed, as are receptor molecules that catalyze the hydrolysis of a predetermined peptide bond.
REFERENCES:
patent: 5030717 (1991-07-01), Tramontano et al.
Schepartz; A. et al. (1987) J. Am. Chem. Soc. 109, 1814-1826.
Iverson, B. L., et al. (1989) Science 243, 1184-1188.
Anon., Science, 243:1119 (1989).
Iverson Brent L.
Lerner Richard A.
Patterson Jr. Charles L.
Scripps Clinic and Research Foundation
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